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Impaired mRNA Expression of the Migration Related Chemokine Receptor CXCR4 in Mesenchymal Stem Cells of COPD Patients
Joint Authors
Antoniou, Katerina M.
Karagiannis, K.
Proklou, A.
Tsitoura, E.
Lasithiotaki, I.
Moraitaki, D.
Sperelakis, I.
Tzanakis, Nikolaos
Kontakis, G.
Kalpadakis, Christina
Source
International Journal of Inflammation
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Defective tissue repair and remodeling are main aspects of Chronic Obstructive Pulmonary Disease (COPD) pathophysiology.
Bone marrow mesenchymal stem cells (BM-MSCs) have been implicated in this direction, as their functional impairment and recruitment could possibly contribute to disease development and progression.
The present study characterizes for the first time the expression of migration related chemokine receptors and their ligands in BM-MSCs from COPD patients.
CXCR4/SDF1a and CCR7/CCL19-CCL21 mRNA levels were evaluated in BM-MSCs obtained from twelve COPD patients and seven healthy donors.
SDF1a protein levels in sera and BM-MSCs’ conditioned media were also evaluated.
CXCR4, SDF1a, CCL19, and CCL21 mRNA levels were significantly reduced in COPD BM-MSCs while CCR7 levels were undetectable.
Notably, SDF1a protein levels were marginally elevated in both patient sera and BM-MSCs’ conditioned media while the increase in SDF1a serum levels significantly correlated with disease severity in COPD.
Our findings show posttranscriptional regulation of SDF1a levels in BM-MSCs of COPD patients and significant downregulation of SDF1a and CXCR4 mRNA indicating an involvement of the SDF1a signaling pathway in the disease pathophysiology.
American Psychological Association (APA)
Karagiannis, K.& Proklou, A.& Tsitoura, E.& Lasithiotaki, I.& Kalpadakis, Christina& Moraitaki, D.…[et al.]. 2017. Impaired mRNA Expression of the Migration Related Chemokine Receptor CXCR4 in Mesenchymal Stem Cells of COPD Patients. International Journal of Inflammation،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1167461
Modern Language Association (MLA)
Karagiannis, K.…[et al.]. Impaired mRNA Expression of the Migration Related Chemokine Receptor CXCR4 in Mesenchymal Stem Cells of COPD Patients. International Journal of Inflammation No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1167461
American Medical Association (AMA)
Karagiannis, K.& Proklou, A.& Tsitoura, E.& Lasithiotaki, I.& Kalpadakis, Christina& Moraitaki, D.…[et al.]. Impaired mRNA Expression of the Migration Related Chemokine Receptor CXCR4 in Mesenchymal Stem Cells of COPD Patients. International Journal of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1167461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167461