Sterile Neuroinflammation and Strategies for Therapeutic Intervention
Joint Authors
Source
International Journal of Inflammation
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-03
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Sterile neuroinflammation is essential for the proper brain development and tissue repair.
However, uncontrolled neuroinflammation plays a major role in the pathogenesis of various disease processes.
The endogenous intracellular molecules so called damage-associated molecular patterns or alarmins or damage signals that are released by activated or necrotic cells are thought to play a crucial role in initiating an immune response.
Sterile inflammatory response that occurs in Alzheimer’s disease (AD), Parkinson’s disease (PD), stroke, hemorrhage, epilepsy, or traumatic brain injury (TBI) creates a vicious cycle of unrestrained inflammation, driving progressive neurodegeneration.
Neuroinflammation is a key mechanism in the progression (e.g., AD and PD) or secondary injury development (e.g., stroke, hemorrhage, stress, and TBI) of multiple brain conditions.
Hence, it provides an opportunity for the therapeutic intervention to prevent progressive tissue damage and loss of function.
The key for developing anti-neuroinflammatory treatment is to minimize the detrimental and neurotoxic effects of inflammation while promoting the beneficial and neurotropic effects, thereby creating ideal conditions for regeneration and repair.
This review outlines how inflammation is involved in the pathogenesis of major nonpathogenic neuroinflammatory conditions and discusses the complex response of glial cells to damage signals.
In addition, emerging experimental anti-neuroinflammatory drug treatment strategies are discussed.
American Psychological Association (APA)
Banjara, Manoj& Ghosh, Chaitali. 2017. Sterile Neuroinflammation and Strategies for Therapeutic Intervention. International Journal of Inflammation،Vol. 2017, no. 2017, pp.1-20.
https://search.emarefa.net/detail/BIM-1167486
Modern Language Association (MLA)
Banjara, Manoj& Ghosh, Chaitali. Sterile Neuroinflammation and Strategies for Therapeutic Intervention. International Journal of Inflammation No. 2017 (2017), pp.1-20.
https://search.emarefa.net/detail/BIM-1167486
American Medical Association (AMA)
Banjara, Manoj& Ghosh, Chaitali. Sterile Neuroinflammation and Strategies for Therapeutic Intervention. International Journal of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-20.
https://search.emarefa.net/detail/BIM-1167486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167486