Comparison of the Performance of Urinary Mycobacterium tuberculosis Antigens Cocktail (ESAT6, CFP10, and MPT64) with Culture and Microscopy in Pulmonary Tuberculosis Patients
Joint Authors
Parwati, Ida
Setiabudiawan, Budi
Sugianli, Adhi Kristianto
Soeroto, Arto Yuwono
Turbawaty, Dewi Kartika
Source
International Journal of Microbiology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Pulmonary tuberculosis (TB) is a major global health problem and is one of the top 10 causes of death worldwide.
Our study aimed to evaluate the performance of urinary Mycobacterium tuberculosis (Mtb) antigens cocktail (ESAT6, CFP10, and MPT64) compared with culture and microscopy.
This descriptive cross-sectional study was conducted in Dr.
Hasan Sadikin General Hospital, Bandung, from January 2014 to October 2016.
A total of 141 pulmonary tuberculosis patients were included.
Sputum samples were examined for acid-fast bacilli (ZN stain) and mycobacterial culture (LJ); the Mtb antigens cocktail was examined in the urine sample.
The positivity rate of TB detection from the three methods was as follows: AFB 52/141 (36.9%), culture 50/141 (35.5%), and urinary Mtb antigens cocktail 95/141 (67.4%).
Sensitivity, specificity, PPV, and NPV of urinary Mtb antigens cocktail were 68.2%, 33%, 31.6%, and 69.6%, respectively.
Validity of combination of both methods with culture as a gold standard yielded sensitivity, specificity, PPV, and NPV of 90%, 28.6%, 40.9%, and 83.8%, respectively.
Combination of urinary Mtb antigens cocktail with AFB as a screening test gives a good sensitivity, although the specificity is reduced.
Urinary Mtb antigens cocktail can be used as screening test for pulmonary tuberculosis.
American Psychological Association (APA)
Turbawaty, Dewi Kartika& Sugianli, Adhi Kristianto& Soeroto, Arto Yuwono& Setiabudiawan, Budi& Parwati, Ida. 2017. Comparison of the Performance of Urinary Mycobacterium tuberculosis Antigens Cocktail (ESAT6, CFP10, and MPT64) with Culture and Microscopy in Pulmonary Tuberculosis Patients. International Journal of Microbiology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1167551
Modern Language Association (MLA)
Turbawaty, Dewi Kartika…[et al.]. Comparison of the Performance of Urinary Mycobacterium tuberculosis Antigens Cocktail (ESAT6, CFP10, and MPT64) with Culture and Microscopy in Pulmonary Tuberculosis Patients. International Journal of Microbiology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1167551
American Medical Association (AMA)
Turbawaty, Dewi Kartika& Sugianli, Adhi Kristianto& Soeroto, Arto Yuwono& Setiabudiawan, Budi& Parwati, Ida. Comparison of the Performance of Urinary Mycobacterium tuberculosis Antigens Cocktail (ESAT6, CFP10, and MPT64) with Culture and Microscopy in Pulmonary Tuberculosis Patients. International Journal of Microbiology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1167551
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167551