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Colorimetric Sensor Based on β-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive Determination
Joint Authors
Ghanizadeh Gerayeli, Farhad
Hosseini, Farnaz
Bagheri, Zohreh
Savardashtaki, Amir
Shabaninejad, Zahra
Amani, Ali Mohammad
Najafipour, Sohrab
Source
International Journal of Analytical Chemistry
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Zidovudine (ZDV) is an antiviral drug against HIV that was approved by the FDA on March, 1987.
It is a reverse transcriptase inhibitor.
This type of drug stops the reproduction of DNA and decreases the amount of the virus in the patients’ blood.
Due to the ability of forming various molecular bonds, silver nanoparticles (AgNPs) are widely used for the detection of large range of agents, including drugs.
In this study, we synthesized AgNP-modified β-cyclodextrin (β-CD) using green synthesis for the sensitive and selective zidovudine (ZDV) determination.
Characterization of nanoparticles was done using different methods including infrared (IR) spectroscopy, ultraviolet-visible (UV-Vis) spectroscopy, transmission electron microscopy (TEM), and also, X-ray diffraction (XRD) patterns.
The AgNP λ-max peak was at approximately 405 nm.
In the presence of ZDV, yellow solution was turned to red color, and surface plasmon absorption band was dramatically centered at 560 nm.
ZDV was determined in the range of 50–500 μM, and the detection limit value was obtained as 42 μM.
The sensor was used to determine ZDV in tablets with good recovery.
American Psychological Association (APA)
Ghanizadeh Gerayeli, Farhad& Hosseini, Farnaz& Bagheri, Zohreh& Savardashtaki, Amir& Shabaninejad, Zahra& Amani, Ali Mohammad…[et al.]. 2020. Colorimetric Sensor Based on β-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive Determination. International Journal of Analytical Chemistry،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1167656
Modern Language Association (MLA)
Ghanizadeh Gerayeli, Farhad…[et al.]. Colorimetric Sensor Based on β-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive Determination. International Journal of Analytical Chemistry No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1167656
American Medical Association (AMA)
Ghanizadeh Gerayeli, Farhad& Hosseini, Farnaz& Bagheri, Zohreh& Savardashtaki, Amir& Shabaninejad, Zahra& Amani, Ali Mohammad…[et al.]. Colorimetric Sensor Based on β-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive Determination. International Journal of Analytical Chemistry. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1167656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167656