Controlled Release of Ropivacaine from Single-Armed (1-PCL) and Four-Armed PCL (4-PCL) Microspheres
Joint Authors
Feng, Xia
Xiong, Wei
Shen, Yue-kun
Dong, Peng
Xiao, Ying
Huang, Xiong-qing
Huang, Wen-qi
Yang, Lu
Source
International Journal of Polymer Science
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sustained release of anesthesia has shown great promise in the treatment of chronic pain in patients.
In this research, we used neutralized ropivacaine as an anesthesia and poly(ε-caprolactone) (PCL) with different architectures to systematically study how these architectures affect the release of ropivacaine.
After optimizing the parameters of the preparation of microspheres, ropivacaine-loaded 1-PCL microspheres and 4-PCL microspheres were obtained.
Fourier Transform infrared spectra (FT-IR) and X-ray diffraction spectra (XRD) confirmed that ropivacaine was encapsulated within the microsphere rather than inserted on the surface of the microsphere.
Ropivacaine was found to be buried deeper in the 1-PCL microsphere than in the 4-PCL microsphere.
In vitro release assay revealed that small crystalline grains interfered with ropivacaine release in 4-PCL microspheres during the initial release period, but then two kinds of microspheres showed a similar ropivacaine release rate.
We basically proved that the architecture of PCL has a negligible effect on ropivacaine release.
Cell proliferation test revealed that the release of products from the microspheres resulted in insignificant toxicity towards mammalian cells.
American Psychological Association (APA)
Xiong, Wei& Shen, Yue-kun& Dong, Peng& Xiao, Ying& Huang, Xiong-qing& Huang, Wen-qi…[et al.]. 2019. Controlled Release of Ropivacaine from Single-Armed (1-PCL) and Four-Armed PCL (4-PCL) Microspheres. International Journal of Polymer Science،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1167736
Modern Language Association (MLA)
Xiong, Wei…[et al.]. Controlled Release of Ropivacaine from Single-Armed (1-PCL) and Four-Armed PCL (4-PCL) Microspheres. International Journal of Polymer Science No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1167736
American Medical Association (AMA)
Xiong, Wei& Shen, Yue-kun& Dong, Peng& Xiao, Ying& Huang, Xiong-qing& Huang, Wen-qi…[et al.]. Controlled Release of Ropivacaine from Single-Armed (1-PCL) and Four-Armed PCL (4-PCL) Microspheres. International Journal of Polymer Science. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1167736
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167736