Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells
Joint Authors
Guo, Hui
Li, Faping
Qiu, Heping
Zheng, Qi
Yang, Chao
Tang, Chao
Hou, Yuchuan
Source
International Journal of Polymer Science
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Chitosan (CS), the second most abundant polysaccharide in nature, has been widely developed as a nanoscopic drug delivery vehicle due to its intriguing characteristics.
In this work, a positively charged CS-based nanogel was designed and synthesized to inhibit the proliferation of breast cancer cell lines.
The model drug of 10-hydroxycamptothecin (HCPT) was entrapped into the core via a facile diffusion to form CS/HCPT.
The characteristics of CS/HCPT were evaluated by assessing particle size, drug loading content, and drug loading efficiency.
Furthermore, cell internalization, cytotoxicity, and apoptosis of CS/HCPT were also investigated in vitro.
The present investigation indicated that the positively charged CS-based nanogel could be potentially used as a promising drug delivery system.
American Psychological Association (APA)
Guo, Hui& Li, Faping& Qiu, Heping& Zheng, Qi& Yang, Chao& Tang, Chao…[et al.]. 2019. Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells. International Journal of Polymer Science،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1167759
Modern Language Association (MLA)
Guo, Hui…[et al.]. Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells. International Journal of Polymer Science No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1167759
American Medical Association (AMA)
Guo, Hui& Li, Faping& Qiu, Heping& Zheng, Qi& Yang, Chao& Tang, Chao…[et al.]. Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells. International Journal of Polymer Science. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1167759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167759