R229Q Polymorphism of NPHS2 Gene in Group of Iraqi Children with Steroid-Resistant Nephrotic Syndrome
Joint Authors
Ali, Shatha Hussain
Mohammed, Rasha Kasim
Saheb, Hussein Ali
Abdulmajeed, Ban A.
Source
International Journal of Nephrology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
The polymorphism R229Q is one of the most commonly reported podocin sequence variations among steroid-resistant nephrotic syndromes (SRNS).
Aim of the Study.
We investigated the frequency and risk of this polymorphism among a group of Iraqi children with SRNS and steroid-sensitive nephrotic syndrome (SSNS).
Patients and Methods.
A prospective case control study which was conducted in Al-Imamein Al-Kadhimein Medical City, spanning the period from the 1st of April 2015 to 30th of November 2015.
Study sample consisted of 54 children having NS, divided into 2 groups: patients group consisted of 27 children with SRNS, and control group involved 27 children with SSNS.
Both were screened by real time polymerase chain reaction for R229Q in exon 5 of NPHS2 gene.
Results.
Molecular study showed R229Q polymorphism in 96.3% of SRNS and 100% of SSNS.
There were no phenotypic or histologic characteristics of patients bearing homozygous R229Q polymorphism and the patients with heterozygous R229Q polymorphism.
Conclusion.
Polymorphism R229Q of NPHS2 gene is prevalent in Iraqi children with SRNS and SSNS.
Further study needs to be done, for other exons and polymorphism of NPHS2 gene in those patients.
American Psychological Association (APA)
Ali, Shatha Hussain& Mohammed, Rasha Kasim& Saheb, Hussein Ali& Abdulmajeed, Ban A.. 2017. R229Q Polymorphism of NPHS2 Gene in Group of Iraqi Children with Steroid-Resistant Nephrotic Syndrome. International Journal of Nephrology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1167790
Modern Language Association (MLA)
Ali, Shatha Hussain…[et al.]. R229Q Polymorphism of NPHS2 Gene in Group of Iraqi Children with Steroid-Resistant Nephrotic Syndrome. International Journal of Nephrology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1167790
American Medical Association (AMA)
Ali, Shatha Hussain& Mohammed, Rasha Kasim& Saheb, Hussein Ali& Abdulmajeed, Ban A.. R229Q Polymorphism of NPHS2 Gene in Group of Iraqi Children with Steroid-Resistant Nephrotic Syndrome. International Journal of Nephrology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1167790
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167790