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Cancer in ANCA-Associated Glomerulonephritis: A Registry-Based Cohort Study
Joint Authors
Bostad, Leif
Myklebust, Tor Åge
Møller, Bjørn
Skrede, Steinar
Bjørneklett, Rune
Sriskandarajah, Sanjeevan
Source
International Journal of Nephrology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Immunosuppressive therapy for antineutrophil cytoplasmic antibody-associated vasculitis has been associated with increased malignancy risk.
Objectives.
To quantify the cancer risk associated with contemporary cyclophosphamide-sparing protocols.
Methods.
Patients from the Norwegian Kidney Biopsy Registry between 1988 and 2012 who had biopsy-verified pauci-immune glomerulonephritis and positive antineutrophil cytoplasmic antibody (ANCA) serology were included.
Standardised incidence ratios (SIRs) were calculated to compare the study cohort with the general population.
Results.
The study cohort included 419 patients.
During 3010 person-years, cancer developed in 41 patients (9.79%); the expected number of cancer cases was 37.5 (8.95%).
The cohort had SIRs as follows: 1.09, all cancer types (95% CI, 0.81 to 1.49); 0.96, all types except nonmelanoma skin cancer (95% CI, 0.69 to 1.34); 3.40, nonmelanoma skin cancer (95% CI, 1.62 to 7.14); 3.52, hematologic cancer (95% CI, 1.32 to 9.37); 2.12, posttransplant cancer (95% CI, 1.01 to 4.44); and 1.53, during the 1–5-year follow-up after diagnosis (95% CI, 1.01 to 2.32).
Conclusions.
Cancer risk did not increase significantly in this cohort with ANCA-associated glomerulonephritis.
However, increased risk of nonmelanoma skin cancer, posttransplant cancer, and hematologic cancer indicates an association between immunosuppression and malignancy.
American Psychological Association (APA)
Sriskandarajah, Sanjeevan& Bostad, Leif& Myklebust, Tor Åge& Møller, Bjørn& Skrede, Steinar& Bjørneklett, Rune. 2017. Cancer in ANCA-Associated Glomerulonephritis: A Registry-Based Cohort Study. International Journal of Nephrology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1167831
Modern Language Association (MLA)
Sriskandarajah, Sanjeevan…[et al.]. Cancer in ANCA-Associated Glomerulonephritis: A Registry-Based Cohort Study. International Journal of Nephrology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1167831
American Medical Association (AMA)
Sriskandarajah, Sanjeevan& Bostad, Leif& Myklebust, Tor Åge& Møller, Bjørn& Skrede, Steinar& Bjørneklett, Rune. Cancer in ANCA-Associated Glomerulonephritis: A Registry-Based Cohort Study. International Journal of Nephrology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1167831
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167831