Denosumab for Male Hemodialysis Patients with Low Bone Mineral Density: A Case-Control Study
Joint Authors
Takami, Hiroya
Washio, Kazunori
Gotoh, Hiromichi
Source
International Journal of Nephrology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Denosumab increases bone mineral density (BMD) in patients not receiving hemodialysis therapy.
However, limited data are available in the literature concerning the use of denosumab in hemodialysis patients.
We treated male hemodialysis patients with low radius BMD with denosumab therapy for 1 year and evaluated its effect on radius BMD.
Seventeen patients were treated with denosumab 60 mg every 6 months, and 20 patients were not treated with denosumab (control group).
At seven days, the mean corrected calcium level decreased from 9.2±0.5 mg to 8.5±0.5 mg (P<0.01), and mean serum phosphorus decreased from 5.0±1.3 mg/dl to 4.2±0.9 mg/dl (P<0.01).
At 1 month, the corrected calcium and serum phosphorus levels were 9.2±0.9 mg/dl and 4.0±1.1 mg/dl, respectively.
At 1 year, BMD increased by 2.6% ± 4.4% in the denosumab group and decreased by 4.5% ± 7.7% in the control group (P<0.001).
In our observational study, denosumab therapy represents an effective treatment for male dialysis patients with low BMD.
American Psychological Association (APA)
Takami, Hiroya& Washio, Kazunori& Gotoh, Hiromichi. 2017. Denosumab for Male Hemodialysis Patients with Low Bone Mineral Density: A Case-Control Study. International Journal of Nephrology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1167833
Modern Language Association (MLA)
Takami, Hiroya…[et al.]. Denosumab for Male Hemodialysis Patients with Low Bone Mineral Density: A Case-Control Study. International Journal of Nephrology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1167833
American Medical Association (AMA)
Takami, Hiroya& Washio, Kazunori& Gotoh, Hiromichi. Denosumab for Male Hemodialysis Patients with Low Bone Mineral Density: A Case-Control Study. International Journal of Nephrology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1167833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167833