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Serial Galactose-Deficient IgA1 Levels in Children with IgA Nephropathy and Healthy Controls
Joint Authors
Moldoveanu, Zina
Novak, Jan
Bursac, Zoran
Julian, Bruce A.
Sanders, John T.
Wyatt, Robert J.
Hastings, M. Colleen
Source
International Journal of Nephrology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Galactose-deficient IgA1 (Gd-IgA1) is a key pathogenic factor for IgA nephropathy (IgAN) and a potential biomarker for the disease.
This study examined serial serum Gd-IgA1 levels over 1 year in 13 children with IgAN and 40 healthy children, to determine whether or not serum Gd-IgA1 levels changed over time.
Subjects were younger than 18 years of age.
Follow-up measurements were scheduled 6 and/or 12 months later.
Analysis of variance and regression models for repeated measures were used to estimate group and time effects.
Serum Gd-IgA1 level was higher in initial samples for IgAN patients compared to those of healthy children (P<0.0001).
Serum Gd-IgA1 levels did not change over time for healthy controls but increased for IgAN patients (P=0.001).
Serum Gd-IgA1 level was elevated for 9 children with IgAN at study entry and remained elevated.
Two of the 4 IgAN patients with initially normal Gd-IgA1 levels had a subsequent elevated level.
The persistent elevation of the serum Gd-IgA1 level in children with IgAN enhances its utility as a potential diagnostic test for IgAN.
American Psychological Association (APA)
Sanders, John T.& Hastings, M. Colleen& Moldoveanu, Zina& Novak, Jan& Julian, Bruce A.& Bursac, Zoran…[et al.]. 2017. Serial Galactose-Deficient IgA1 Levels in Children with IgA Nephropathy and Healthy Controls. International Journal of Nephrology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1167842
Modern Language Association (MLA)
Sanders, John T.…[et al.]. Serial Galactose-Deficient IgA1 Levels in Children with IgA Nephropathy and Healthy Controls. International Journal of Nephrology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1167842
American Medical Association (AMA)
Sanders, John T.& Hastings, M. Colleen& Moldoveanu, Zina& Novak, Jan& Julian, Bruce A.& Bursac, Zoran…[et al.]. Serial Galactose-Deficient IgA1 Levels in Children with IgA Nephropathy and Healthy Controls. International Journal of Nephrology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1167842
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167842