Combined Effect of Lentinan and Cisplatin on Cytokines IL-6, TNF-α, and TGF-β in Tumor Therapy
Joint Authors
Liu, Xu-dong
Li, Min
Li, Wan-xiang
Wang, Qing-yu
Zhang, Hong-xia
Source
International Journal of Polymer Science
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Lentinan is a biologically active ingredient isolated from the fruiting body of Lentinula edodes (shiitake) and has antitumor properties.
Cytokines, at the same time, are a key factor in regulating immune responses in physiological and pathological states.
Many cytokines have shown positive effect on different malignancies in clinical trials.
Studies have shown that such cytokines as IL6, TNF-α, and TGF-β play a quite important role in the formation of tumor microenvironment.
In this study, we investigated the antitumor effect of combined medication of lentinan and cisplatin, another antitumor drug, and its impact on cytokines IL-6, TNF-α, and TGF-β in the treatment of tumor.
The results showed that lentinan enhanced the cytotoxic effect of cisplatin on tumor cells.
Furthermore, it was proved that the combined treatment of lentinan and cisplatin enhanced the inhibitory effect of cisplatin on the expression of IL-6, TNF- α, TGF-β and tumor growth in mice bearing human ovarian cancer xenograft, human prostate tumor xenograft, and human non-small cell lung cancer xenograft.
American Psychological Association (APA)
Liu, Xu-dong& Li, Min& Li, Wan-xiang& Wang, Qing-yu& Zhang, Hong-xia. 2019. Combined Effect of Lentinan and Cisplatin on Cytokines IL-6, TNF-α, and TGF-β in Tumor Therapy. International Journal of Polymer Science،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1168002
Modern Language Association (MLA)
Liu, Xu-dong…[et al.]. Combined Effect of Lentinan and Cisplatin on Cytokines IL-6, TNF-α, and TGF-β in Tumor Therapy. International Journal of Polymer Science No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1168002
American Medical Association (AMA)
Liu, Xu-dong& Li, Min& Li, Wan-xiang& Wang, Qing-yu& Zhang, Hong-xia. Combined Effect of Lentinan and Cisplatin on Cytokines IL-6, TNF-α, and TGF-β in Tumor Therapy. International Journal of Polymer Science. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1168002
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1168002