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Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery
Joint Authors
García-Couce, Jomarien
Bada-Rivero, Nancy
López Hernández, Orestes D.
Nogueira, Antonio
Caracciolo, Pablo C.
Abraham, Gustavo A.
Ramón Hernández, José A.
Peniche, Carlos
Source
International Journal of Polymer Science
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Chitosan (CS) microparticles loaded with dexamethasone were prepared by spray drying, followed by coating with a pH-dependent interpolymer complex based on poly(acrylic acid)/poly(vinyl pyrrolidone) using an water-in-oil emulsion technique.
The aim of this research was to evaluate the influence of PAA/PVP coating on the release of dexamethasone from loaded chitosan microparticles, in simulated gastric fluid (SGF, pH=1.2) and simulated intestinal fluid (SIF, pH=6.8).
The release of dexamethasone from uncoated loaded CS microparticles was similar in both fluids, and almost complete release of the drug was achieved in 5 hours.
In the coated loaded CS microparticles, the release of dexamethasone in SGF was reduced considerably, very close to zero, due to the interpolymer complex formation at low pH, demonstrating that this system applied as pH-dependent coating has a potential as a site-specific delivery system.
American Psychological Association (APA)
García-Couce, Jomarien& Bada-Rivero, Nancy& López Hernández, Orestes D.& Nogueira, Antonio& Caracciolo, Pablo C.& Abraham, Gustavo A.…[et al.]. 2019. Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery. International Journal of Polymer Science،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1168006
Modern Language Association (MLA)
García-Couce, Jomarien…[et al.]. Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery. International Journal of Polymer Science No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1168006
American Medical Association (AMA)
García-Couce, Jomarien& Bada-Rivero, Nancy& López Hernández, Orestes D.& Nogueira, Antonio& Caracciolo, Pablo C.& Abraham, Gustavo A.…[et al.]. Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery. International Journal of Polymer Science. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1168006
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1168006