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Acetylsalicylic Acid (ASA) on HydroxyethylcellulosePolyacrylamide Gel (HECPAAm) as a Proposal for a Dermatological Compress: Mathematical Modeling of ASA Release Kinetics
Joint Authors
Rivera-Armenta, José L.
Morales-Cepeda, A. B.
Castillo-Miranda, Claudia Alicia
Castro-Guerrero, Carlos Fernando
Velasco-Ocejo, Hugo Alberto
González-Sánchez, Jorge Alberto
Flores-Cerda, Gabriel Osmar
Ramos-Galvan, Claudia Esmeralda
Source
International Journal of Polymer Science
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Currently, acne in adolescents and adults is caused by an infection in follicles caused by hormonal changes, stress, water pollution, air, and earth; the last one comes into contact with the skin through the hands of patients.
This project presents the incorporation of acetylsalicylic acid (ASA) to the hydroxyethylcellulose/polyacrylamide gel (HEC/PAAm) in the synthesis of gel or by its swelling.
The results show us that the incorporation of ASA is possible by both methods; first, the incorporation by synthesis of degradation of the gel is more visible.
The infrared spectroscopic analysis shows the functional groups of gel and ASA, 2921 and 2863 cm−1, whose assignments correspond to CH3 and CH2 groups, which are part of both the polymer and the ASA molecule, which confirms the interaction between the two groups.
The microscopy photographs (SEM) show on the surface the drug in irregular whitish orthorhombic forms due to swelling; arborescent structures are observed in the case of the incorporation of the ASA drug by synthesis.
Swelling kinetics has a Fickian form.
The Higuchi model conforms to the release of ASA because the level of confidence is 90%.
This gel was allowed to release 0.35 mg/hour, thus allowing the patient to have a continuous form of the release, in the affected area in a short period of time.
American Psychological Association (APA)
Castillo-Miranda, Claudia Alicia& Castro-Guerrero, Carlos Fernando& Velasco-Ocejo, Hugo Alberto& González-Sánchez, Jorge Alberto& Flores-Cerda, Gabriel Osmar& Ramos-Galvan, Claudia Esmeralda…[et al.]. 2019. Acetylsalicylic Acid (ASA) on HydroxyethylcellulosePolyacrylamide Gel (HECPAAm) as a Proposal for a Dermatological Compress: Mathematical Modeling of ASA Release Kinetics. International Journal of Polymer Science،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1168030
Modern Language Association (MLA)
Castillo-Miranda, Claudia Alicia…[et al.]. Acetylsalicylic Acid (ASA) on HydroxyethylcellulosePolyacrylamide Gel (HECPAAm) as a Proposal for a Dermatological Compress: Mathematical Modeling of ASA Release Kinetics. International Journal of Polymer Science No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1168030
American Medical Association (AMA)
Castillo-Miranda, Claudia Alicia& Castro-Guerrero, Carlos Fernando& Velasco-Ocejo, Hugo Alberto& González-Sánchez, Jorge Alberto& Flores-Cerda, Gabriel Osmar& Ramos-Galvan, Claudia Esmeralda…[et al.]. Acetylsalicylic Acid (ASA) on HydroxyethylcellulosePolyacrylamide Gel (HECPAAm) as a Proposal for a Dermatological Compress: Mathematical Modeling of ASA Release Kinetics. International Journal of Polymer Science. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1168030
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1168030