In Vitro-In Vivo Correlation for the Degradation of Tetra-PEG Hydrogel Microspheres with Tunable β-Eliminative Crosslink Cleavage Rates
Joint Authors
Henise, Jeff
Fontaine, Shaun D.
Hearn, Brian R.
Pfaff, Samuel J.
Schneider, Eric L.
Malato, Julia
Wang, Donghui
Hann, Byron
Ashley, Gary W.
Santi, Daniel V.
Source
International Journal of Polymer Science
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The degradation of Tetra-PEG hydrogels containing β-eliminative crosslinks has been studied in order to provide an in vitro-in vivo correlation for the use of these hydrogels in our chemically controlled drug delivery system.
We measured time-dependent gel mass loss and ultrasound volume changes of 13 subcutaneously implanted Tetra-PEG hydrogel microspheres having degradation times ranging from ~3 to 250 days.
Applying a previously developed model of Tetra-PEG hydrogel degradation, the mass changes correlate well with the in vitro rates of crosslink cleavage and hydrogel degelation.
These results allow prediction of in vivo biodegradation properties of these hydrogels based on readily obtained in vitro rates, despite having degradation times that span 2 orders of magnitude.
These results support the optimization of drug-releasing hydrogels and their development into long-acting therapeutics.
The use of ultrasound volume measurements further provides a noninvasive technique for monitoring hydrogel degradation in the subcutaneous space.
American Psychological Association (APA)
Henise, Jeff& Fontaine, Shaun D.& Hearn, Brian R.& Pfaff, Samuel J.& Schneider, Eric L.& Malato, Julia…[et al.]. 2019. In Vitro-In Vivo Correlation for the Degradation of Tetra-PEG Hydrogel Microspheres with Tunable β-Eliminative Crosslink Cleavage Rates. International Journal of Polymer Science،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1168415
Modern Language Association (MLA)
Henise, Jeff…[et al.]. In Vitro-In Vivo Correlation for the Degradation of Tetra-PEG Hydrogel Microspheres with Tunable β-Eliminative Crosslink Cleavage Rates. International Journal of Polymer Science No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1168415
American Medical Association (AMA)
Henise, Jeff& Fontaine, Shaun D.& Hearn, Brian R.& Pfaff, Samuel J.& Schneider, Eric L.& Malato, Julia…[et al.]. In Vitro-In Vivo Correlation for the Degradation of Tetra-PEG Hydrogel Microspheres with Tunable β-Eliminative Crosslink Cleavage Rates. International Journal of Polymer Science. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1168415
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1168415