![](/images/graphics-bg.png)
Therapy of Prostate Cancer by Nanoyam Polysaccharide
Joint Authors
Zhai, Zhaohui
Peng, Cheng
Han, Bo
Wang, Baishan
Zhao, Gaoyang
Yuan, Fang
Zhao, Yeyu
Liang, Liang
Liu, Dingge
Shen, Yanping
Source
International Journal of Polymer Science
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We evaluated the effect and mechanism of yam polysaccharide on the proliferation of the prostatic cancer cell line and tumor-bearing mice.
The effect of nanoyam polysaccharide on prostatic cancer cell line PC-3 was measured using the scratch adhesion test and flow cytometry.
The growth effect induced by nanoyam polysaccharide was detected with the CCK-8 test.
The levels of caspase-3 protein were determined with Western blot.
In our data, nanoyam polysaccharide presented inhibitory effect on the proliferation of PC-3.
The scratch adhesion test showed that the rate of wound healing in the intervention group was significantly lower than that in the control group (p<0.05).
Flow cytometry assay showed that, after treatment with nanoyam polysaccharide, the apoptosis rate in the intervention group was significantly lower than that in the control group (45.8%±2.6%, 25.8%±3.1%; p<0.05).
Western blot assay showed upregulated levels of caspase-3 in the intervention group, compared to the control group (p<0.05).
Our results suggested that nanoyam polysaccharide strongly suppressed the growth of prostatic cancer by inducing the overexpression of caspase-3 and may be a potent anticancer strategy.
American Psychological Association (APA)
Peng, Cheng& Han, Bo& Wang, Baishan& Zhao, Gaoyang& Yuan, Fang& Zhao, Yeyu…[et al.]. 2019. Therapy of Prostate Cancer by Nanoyam Polysaccharide. International Journal of Polymer Science،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1168423
Modern Language Association (MLA)
Peng, Cheng…[et al.]. Therapy of Prostate Cancer by Nanoyam Polysaccharide. International Journal of Polymer Science No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1168423
American Medical Association (AMA)
Peng, Cheng& Han, Bo& Wang, Baishan& Zhao, Gaoyang& Yuan, Fang& Zhao, Yeyu…[et al.]. Therapy of Prostate Cancer by Nanoyam Polysaccharide. International Journal of Polymer Science. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1168423
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1168423