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Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice
Joint Authors
Komissarov, Andrey B.
Prokopyeva, Elena A.
Zinserling, Vsevolod A.
Bae, You-Chan
Kwon, Yongkuk
Kurskaya, Olga G.
Sobolev, Ivan A.
Kozhin, Peter M.
Fadeev, Artem
Petrov, Vladimir
Shestopalov, Alexander M.
Sharshov, Kirill A.
Source
Interdisciplinary Perspectives on Infectious Diseases
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The emergence of novel highly pathogenic avian influenza viruses (HPAIVs) in migratory birds raises serious concerns as these viruses have the potential to spread during fall migration.
We report the identification of novel HPAIV A(H5N8) clade 2.3.4.4 virus that was isolated from sick domestic duck at commercial farm during the second wave of spread that began in October and affected poultry (ducks; chiсkens) in several European regions of Russia and Western Siberia in 2016.
The strain was highly lethal in experimental infection of chickens and mice with IVPI = 2.34 and M L D 50 = 1.3 log 10 EI D 50 , accordingly.
Inoculation of chickens with the HPAIV A/H5N8 demonstrated neuroinvasiveness, multiorgan failure, and death of chickens on the 3 r d day post inoculation.
Virus replicated in all collected organ samples in high viral titers with the highest titer in the brain (6.75±0.1 l o g 10 TCI D 50 /ml).
Effective virus replication was found in the following cells: neurons and glial cells of a brain; alveolar cells and macrophages of lungs; epithelial cells of a small intestine; hepatocytes and Kupffer cells of a liver; macrophages and endothelial cells of a spleen; and the tubular epithelial cells of kidneys.
These findings advance our understanding of histopathological effect of A(H5N8) HPAIV infection.
American Psychological Association (APA)
Prokopyeva, Elena A.& Zinserling, Vsevolod A.& Bae, You-Chan& Kwon, Yongkuk& Kurskaya, Olga G.& Sobolev, Ivan A.…[et al.]. 2019. Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1168763
Modern Language Association (MLA)
Prokopyeva, Elena A.…[et al.]. Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice. Interdisciplinary Perspectives on Infectious Diseases No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1168763
American Medical Association (AMA)
Prokopyeva, Elena A.& Zinserling, Vsevolod A.& Bae, You-Chan& Kwon, Yongkuk& Kurskaya, Olga G.& Sobolev, Ivan A.…[et al.]. Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice. Interdisciplinary Perspectives on Infectious Diseases. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1168763
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1168763