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Advances in Hybrid Polymer-Based Materials for Sustained Drug Release
Joint Authors
de Paula, Eneida
Ribeiro, Lígia N. M.
Alcântara, Ana C. S.
Rodrigues da Silva, Gustavo H.
Franz-Montan, Michelle
Nista, Silvia V. G.
Castro, Simone R.
Couto, Verônica M.
Guilherme, Viviane A.
Source
International Journal of Polymer Science
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-01
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The use of biomaterials composed of organic pristine components has been successfully described in several purposes, such as tissue engineering and drug delivery.
Drug delivery systems (DDS) have shown several advantages over traditional drug therapy, such as greater therapeutic efficacy, prolonged delivery profile, and reduced drug toxicity, as evidenced by in vitro and in vivo studies as well as clinical trials.
Despite that, there is no perfect delivery carrier, and issues such as undesirable viscosity and physicochemical stability or inability to efficiently encapsulate hydrophilic/hydrophobic molecules still persist, limiting DDS applications.
To overcome that, biohybrid systems, originating from the synergistic assembly of polymers and other organic materials such as proteins and lipids, have recently been described, yielding molecularly planned biohybrid systems that are able to optimize structures to easily interact with the targets.
This work revised the biohybrid DDS clarifying their advantages, limitations, and future perspectives in an attempt to contribute to further research of innovative and safe biohybrid polymer-based system as biomaterials for the sustained release of active molecules.
American Psychological Association (APA)
Ribeiro, Lígia N. M.& Alcântara, Ana C. S.& Rodrigues da Silva, Gustavo H.& Franz-Montan, Michelle& Nista, Silvia V. G.& Castro, Simone R.…[et al.]. 2017. Advances in Hybrid Polymer-Based Materials for Sustained Drug Release. International Journal of Polymer Science،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1168797
Modern Language Association (MLA)
Ribeiro, Lígia N. M.…[et al.]. Advances in Hybrid Polymer-Based Materials for Sustained Drug Release. International Journal of Polymer Science No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1168797
American Medical Association (AMA)
Ribeiro, Lígia N. M.& Alcântara, Ana C. S.& Rodrigues da Silva, Gustavo H.& Franz-Montan, Michelle& Nista, Silvia V. G.& Castro, Simone R.…[et al.]. Advances in Hybrid Polymer-Based Materials for Sustained Drug Release. International Journal of Polymer Science. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1168797
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1168797