Effect of Film-Forming Polymers on Release of Naftifine Hydrochloride from Nail Lacquers
Joint Authors
Briedis, Vitalis
Šveikauskaitė, Indrė
Source
International Journal of Polymer Science
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The successful topical therapy of onychomycosis depends on effective drug release and penetration into nail, which can be achieved by using an adequately developed delivery system.
This study evaluated and compared effect of film-forming polymers Eudragit RL100, Eudragit RS100, and ethyl cellulose on naftifine hydrochloride release from experimental nail lacquer formulations.
Quality of formulations was evaluated by determining drying time and water resistance.
Interactions between active pharmaceutical ingredient and excipients were investigated using microcalorimetry and FT-IR.
Optimization of nail lacquer formulations was performed by naftifine hydrochloride release testing.
Release of naftifine hydrochloride increased with increasing concentration of Eudragit RL100.
Plasticizer triacetin affected the release of naftifine hydrochloride, when Eudragit RS100 polymer was used.
Ethyl cellulose polymer was determined to be not applicable for naftifine hydrochloride nail lacquer formulations.
Two compositions of nail lacquers were optimized and could be used in further development of transungual delivery systems.
American Psychological Association (APA)
Šveikauskaitė, Indrė& Briedis, Vitalis. 2017. Effect of Film-Forming Polymers on Release of Naftifine Hydrochloride from Nail Lacquers. International Journal of Polymer Science،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1168812
Modern Language Association (MLA)
Šveikauskaitė, Indrė& Briedis, Vitalis. Effect of Film-Forming Polymers on Release of Naftifine Hydrochloride from Nail Lacquers. International Journal of Polymer Science No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1168812
American Medical Association (AMA)
Šveikauskaitė, Indrė& Briedis, Vitalis. Effect of Film-Forming Polymers on Release of Naftifine Hydrochloride from Nail Lacquers. International Journal of Polymer Science. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1168812
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1168812