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Bioinspired Polyethersulfone Membrane Design via Blending with Functional Polyurethane
Joint Authors
Zhao, Changsheng
Han, Mei
Liu, Qiang
Su, Baihai
Sun, Shudong
Source
International Journal of Polymer Science
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Polyurethanes (PUs) are currently considered to be biocompatible materials but limited by a low resistance to thrombus.
We therefore design a heparin-like PU (HLPU) to modify polyethersulfone (PES) membranes approaching integrated antifouling and antithrombotic properties by bioinspiration of heparin structure.
Poly(vinyl pyrrolidone)-HLPU (PVP-HLPU) was synthesized via reversible addition-fragmentation chain transfer polymerization of VP using PU as a macroinitiator and then sulfonated by concentrated H2SO4.
FTIR and NMR results demonstrated the successful synthesis of PVP-HLPU.
By incorporation of PVP-HLPU, the cross-sectional structure of PES composite membranes altered from finger-like structure to sponge-like structure resulting in tunable permeability.
The increased hydrophilicity verified by water contact angles benefited both the permeability and antifouling property.
As a consequence, the composite membranes showed good blood compatibility, including decreased protein adsorption, suppressed platelet adhesion, lowered thrombin-antithrombin III generation, reduced complement activation, and prolonged clotting times.
Interestingly, the PVP-capped HLPU showed better blood compatibility compared to polyethyleneglycol-capped and citric acid-capped HLPUs.
The results demonstrated the enhanced antifouling and antithrombotic properties of PES hemodialysis membranes by the introduction of functional HLPUs.
Also, the proposed method may forward the fabrication of hemocompatible membranes via bioinspired surface design.
American Psychological Association (APA)
Han, Mei& Liu, Qiang& Su, Baihai& Sun, Shudong& Zhao, Changsheng. 2017. Bioinspired Polyethersulfone Membrane Design via Blending with Functional Polyurethane. International Journal of Polymer Science،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1168851
Modern Language Association (MLA)
Han, Mei…[et al.]. Bioinspired Polyethersulfone Membrane Design via Blending with Functional Polyurethane. International Journal of Polymer Science No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1168851
American Medical Association (AMA)
Han, Mei& Liu, Qiang& Su, Baihai& Sun, Shudong& Zhao, Changsheng. Bioinspired Polyethersulfone Membrane Design via Blending with Functional Polyurethane. International Journal of Polymer Science. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1168851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1168851