Modeling the Effects of Vaccination and Treatment on Tuberculosis Transmission Dynamics

Abstract EN

In this study, we develop and analyze a deterministic mathematical model for tuberculosis (TB) transmission dynamics.

The model includes vaccination for newborns and treatment for both high-risk latent and active TB patients.

The stability of disease-free equilibrium point is discussed in detail.

In the numerical simulation, the model parameters are estimated using reported TB incidence data in Ethiopia from the years 2003 to 2017, and R 0 is calculated as R 0 ≈2.13.

Finally, the sensitivity indices of R 0 with respect to the model parameters are performed, and their corresponding graphical results are presented.

Our results quantify the positive influence of vaccination and the treatment for high-risk latent and active TB patients on the control of tuberculosis.