Application of TLC for Evaluation of the Lipophilicity of Newly Synthetized Esters: Betulin Derivatives
Joint Authors
Bober, Katarzyna
Bębenek, Ewa
Boryczka, Stanisław
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The problem of designing a new drug is nowadays very important for researches representing many branches of science.
This work considers the usefulness of the analytical method such as thin-layer chromatography for the lipophilicity of newly synthesized compounds, betulin derivatives, which could be potential drugs with anticancer activity.
The two mobile phases were used for the purpose of experimental determination of lipophilicity for mono- and diesters investigated.
The first mobile phase consists of acetate and Tris buffer, whilst the second consists of 1,4-dioxane and acetate buffer.
The value of the retardation factor was recalculation into the RM value, and then RM0 values were obtained by extrapolating acetone or 1,4-dioxane concentration to zero.
The chromatographic data of lipophilicity were correlated with theoretically obtained values of ALOGPS, AClogP, miLogP, ALOGP, MLOGP, XLOGP2, and XLOGP3.
The particular correlation equations were obtained.
The cluster analysis was also used to find similarity between the esters investigated on the basis of the experimental or theoretical value of lipophilicity obtained.
The good correlation between experimentally and theoretically calculated lipophilicity gives the possibility of prediction of this value on the basis of the correlation equation.
On the basis of similarity analysis was stated strong connections between the structure and the value of lipophilicity, for both experimental and theoretical values.
American Psychological Association (APA)
Bober, Katarzyna& Bębenek, Ewa& Boryczka, Stanisław. 2019. Application of TLC for Evaluation of the Lipophilicity of Newly Synthetized Esters: Betulin Derivatives. Journal of Analytical Methods in Chemistry،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1169016
Modern Language Association (MLA)
Bober, Katarzyna…[et al.]. Application of TLC for Evaluation of the Lipophilicity of Newly Synthetized Esters: Betulin Derivatives. Journal of Analytical Methods in Chemistry No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1169016
American Medical Association (AMA)
Bober, Katarzyna& Bębenek, Ewa& Boryczka, Stanisław. Application of TLC for Evaluation of the Lipophilicity of Newly Synthetized Esters: Betulin Derivatives. Journal of Analytical Methods in Chemistry. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1169016
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1169016