Nonirritant and Cytocompatible Tinospora cordifolia Nanoparticles for Topical Antioxidant Treatments
Joint Authors
Vega-Baudrit, José
González-Masís, Jeimmy
Cubero-Sesin, Jorge M.
Corrales-Ureña, Yendry Regina
González-Camacho, Sara
Mora-Ugalde, Nohelia
Rischka, Klaus
Verma, Virendra
Gonzalez-Paz, Rodolfo J.
Source
International Journal of Biomaterials
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Tinospora cordifolia extract contains antioxidants such as polyphenols, and thus, it has been used as a natural phytochemical antioxidant therapeutic agent.
Many of these compounds are insoluble or only partially soluble in water.
In this study, we produced a novel aqueous nanoparticle formulation, with an average particle size of 182.9 ± 3.8 nm, to improve the dispersion of the bioactive compounds in water and to increment its bioavailability.
The nanoparticles are composed of polyphenols, alkaloids, and glycosides.
We studied the effect of this nanoparticle formulation on mouse 3T3 fibroblast cell viability and New Zealand rabbit dermal irritability tests.
Concentrations of 2.5, 25, and 250 µg/mL resulted in similar cell viability to cells in culture media.
An intermediate concentration of 12.45 mg/ml was used for the acute dermal irritability test.
There were no severe alterations that compromised animal health.
These results represent a precedent for application of such nanoparticles derived from plant stems, such as Tinospora cordifolia, in biomedicine and in antiaging cosmetic treatments.
American Psychological Association (APA)
González-Masís, Jeimmy& Cubero-Sesin, Jorge M.& Corrales-Ureña, Yendry Regina& González-Camacho, Sara& Mora-Ugalde, Nohelia& Vega-Baudrit, José…[et al.]. 2020. Nonirritant and Cytocompatible Tinospora cordifolia Nanoparticles for Topical Antioxidant Treatments. International Journal of Biomaterials،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1169206
Modern Language Association (MLA)
González-Masís, Jeimmy…[et al.]. Nonirritant and Cytocompatible Tinospora cordifolia Nanoparticles for Topical Antioxidant Treatments. International Journal of Biomaterials No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1169206
American Medical Association (AMA)
González-Masís, Jeimmy& Cubero-Sesin, Jorge M.& Corrales-Ureña, Yendry Regina& González-Camacho, Sara& Mora-Ugalde, Nohelia& Vega-Baudrit, José…[et al.]. Nonirritant and Cytocompatible Tinospora cordifolia Nanoparticles for Topical Antioxidant Treatments. International Journal of Biomaterials. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1169206
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1169206