Comparative Evaluation of Bone Repair with Four Different Bone Substitutes in Critical Size Defects
Joint Authors
Faverani, Leonardo P.
Grossi-Oliveira, Gustavo
Mendes, Bruno Coelho
Braga Polo, Tárik Ocon
Batista Mendes, Gabriel Cury
Lima, Valthierre Nunes de
Ribeiro Júnior, Paulo Domingos
Okamoto, Roberta
Magro-Filho, Osvaldo
Source
International Journal of Biomaterials
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study evaluated the osteoconductive potential of four biomaterials used to fill bone defects.
For this, 24 male Albino rabbits were submitted to the creation of a bilateral 8 mm calvarial bone defect.
The animals were divided into four groups—bovine hydroxyapatite, Bio-Oss® (BIO); Lumina-Bone Porous® (LBP); Bonefill® (BFL); and an alloplastic material, Clonos® (CLN)—and were euthanized at 14 and 40 days.
The samples were subjected to histological and histometric analysis for newly formed bone area.
Immunohistochemical analysis for Runt-related transcription factor 2 (Runx2), vascular endothelial growth factor (VEGF), and osteocalcin (OC) was performed.
After statistical analysis, the CLN group showed greater new bone formation (NB) in both periods analyzed (p<0.05).
At 14 days, the NB showed greater values in BIO in relation to LBP and BFL groups; however, after 40 days, the LBP group surpassed the results of BIO (p<0.001).
The immunostaining showed a decrease in Runx2 intensity in BIO after 40 days, while it increased for LBP (p<0.05).
The CLN showed increased OC compared to the other groups in both periods analyzed (p<0.05).
Therefore, CLN showed the best osteoconductive behavior in critical defects in rabbit calvaria, and BFL showed the lowest osteoconductive property.
American Psychological Association (APA)
Grossi-Oliveira, Gustavo& Faverani, Leonardo P.& Mendes, Bruno Coelho& Braga Polo, Tárik Ocon& Batista Mendes, Gabriel Cury& Lima, Valthierre Nunes de…[et al.]. 2020. Comparative Evaluation of Bone Repair with Four Different Bone Substitutes in Critical Size Defects. International Journal of Biomaterials،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1169220
Modern Language Association (MLA)
Grossi-Oliveira, Gustavo…[et al.]. Comparative Evaluation of Bone Repair with Four Different Bone Substitutes in Critical Size Defects. International Journal of Biomaterials No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1169220
American Medical Association (AMA)
Grossi-Oliveira, Gustavo& Faverani, Leonardo P.& Mendes, Bruno Coelho& Braga Polo, Tárik Ocon& Batista Mendes, Gabriel Cury& Lima, Valthierre Nunes de…[et al.]. Comparative Evaluation of Bone Repair with Four Different Bone Substitutes in Critical Size Defects. International Journal of Biomaterials. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1169220
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1169220