Osteopromotion Capacity of Bovine Cortical Membranes in Critical Defects of Rat Calvaria: Histological and Immunohistochemical Analysis

Joint Authors

Danieletto-Zanna, Carolina Ferrairo
Bizelli, Vinícius Ferreira
Ramires, Guilherme André Del Arco
Francatti, Tamires Melo
Carvalho, Paulo Sérgio Perri de
Bassi, Ana Paula Farnezi

Source

International Journal of Biomaterials

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-02-18

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Medicine

Abstract EN

Membranes that aid the guided bone regeneration (GBR) process have been the subject of studies of compatible biomaterials that contribute to this repair process.

The present study compared different membranes used in critical-size defects of rat calvaria by assessing GBR as well as histological, histomorphometric, and immunohistochemical reactions.

Forty-eight male albino Wistar rats were randomly allocated into four groups (n = 12 each), namely, C: membrane-free control group (only blood clot, negative control group); BG: porcine collagen membrane group (Bio-Gide®, positive control group); GD: bovine cortical membrane group (first experimental group); and GDF: thicker bovine cortical membrane group (second experimental group).

Rats were euthanized at 30 and 60 days postoperatively.

Quantitative data from the histometric analysis were submitted to two-way ANOVA and Tukey’s posttest when p<0.05.

Histomorphometric results of the thicker bovine cortical membrane at 30 and 60 days were promising, showing improved new bone formation values (p<0.05), and the CD group presented similar results in both analysis periods, being surpassed only by the GDF group (p<0.05).

The immunohistochemical results were associated with the histomorphometric data.

A less-thick membrane also assisted in GBR.

All membranes promoted GBR, especially the positive control and experimental groups.

American Psychological Association (APA)

Danieletto-Zanna, Carolina Ferrairo& Bizelli, Vinícius Ferreira& Ramires, Guilherme André Del Arco& Francatti, Tamires Melo& Carvalho, Paulo Sérgio Perri de& Bassi, Ana Paula Farnezi. 2020. Osteopromotion Capacity of Bovine Cortical Membranes in Critical Defects of Rat Calvaria: Histological and Immunohistochemical Analysis. International Journal of Biomaterials،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1169227

Modern Language Association (MLA)

Danieletto-Zanna, Carolina Ferrairo…[et al.]. Osteopromotion Capacity of Bovine Cortical Membranes in Critical Defects of Rat Calvaria: Histological and Immunohistochemical Analysis. International Journal of Biomaterials No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1169227

American Medical Association (AMA)

Danieletto-Zanna, Carolina Ferrairo& Bizelli, Vinícius Ferreira& Ramires, Guilherme André Del Arco& Francatti, Tamires Melo& Carvalho, Paulo Sérgio Perri de& Bassi, Ana Paula Farnezi. Osteopromotion Capacity of Bovine Cortical Membranes in Critical Defects of Rat Calvaria: Histological and Immunohistochemical Analysis. International Journal of Biomaterials. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1169227

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1169227