Determination of Six Macrolide Antibiotics in Chicken Sample by Liquid Chromatography-Tandem Mass Spectrometry Based on Solid Phase Extraction
Joint Authors
Lan, Chen
Yin, Dan
Yang, Zhicong
Zhao, Wuduo
Chen, Yanlong
Zhang, Wenfen
Zhang, Shusheng
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-24
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In this paper, a simple and effective method for the determination of six macrolide antibiotics (MACs), including tylosin, tilmicosin, azithromycin, clarithromycin, roxithromycin, and kitasamycin, in the chicken sample using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed based on a self-built porous aromatic framework- (PAF-) based solid phase sorbent.
The main parameters influencing the extraction efficiency, such as sorbent amounts, type of the eluent, pH of the sample, and the eluent volume, were evaluated.
Under the optimized condition, the limits of detection were from 0.2 to 0.5 μg·kg−1.
The recoveries of the method ranged from 82.1% to 101.4% with the relative standard deviations less than 11.1%.
All the results demonstrated that the established method is potential for the determination of macrolide antibiotics in food safety analysis and monitoring.
American Psychological Association (APA)
Lan, Chen& Yin, Dan& Yang, Zhicong& Zhao, Wuduo& Chen, Yanlong& Zhang, Wenfen…[et al.]. 2019. Determination of Six Macrolide Antibiotics in Chicken Sample by Liquid Chromatography-Tandem Mass Spectrometry Based on Solid Phase Extraction. Journal of Analytical Methods in Chemistry،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1169245
Modern Language Association (MLA)
Lan, Chen…[et al.]. Determination of Six Macrolide Antibiotics in Chicken Sample by Liquid Chromatography-Tandem Mass Spectrometry Based on Solid Phase Extraction. Journal of Analytical Methods in Chemistry No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1169245
American Medical Association (AMA)
Lan, Chen& Yin, Dan& Yang, Zhicong& Zhao, Wuduo& Chen, Yanlong& Zhang, Wenfen…[et al.]. Determination of Six Macrolide Antibiotics in Chicken Sample by Liquid Chromatography-Tandem Mass Spectrometry Based on Solid Phase Extraction. Journal of Analytical Methods in Chemistry. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1169245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1169245