Rat Olfactory Mucosa Mesenchymal StemStromal Cells (OM-MSCs): A Characterization Study
Joint Authors
Mauricio, Ana C.
Rêma, A.
Caseiro, Ana Rita
Alvites, Rui D.
Branquinho, Mariana V.
Santos Pedrosa, Sílvia
Porto, Beatriz
Oliveira, Cláudia
Magalhães, Rui
Varejão, A. S. P.
Geuna, Stefano
Faria, F.
Teixeira, Paula
Amorim, Irina
Source
International Journal of Cell Biology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-29
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Stem/stromal cell-based therapies are a branch of regenerative medicine and stand as an attractive option to promote the repair of damaged or dysfunctional tissues and organs.
Olfactory mucosa mesenchymal stem/stromal cells have been regarded as a promising tool in regenerative therapies because of their several favorable properties such as multipotency, high proliferation rate, helpful location, and few associated ethical issues.
These cells are easily accessible in the nasal cavity of most mammals, including the rat, can be easily applied in autologous treatments, and do not cope with most of the obstacles associated with the use of other stem cells.
Despite this, its application in preclinical trials and in both human and animal patients is still limited because of the small number of studies performed so far and to the nonexistence of a standard and unambiguous protocol for collection, isolation, and therapeutic application.
In the present work a validation of a protocol for isolation, culture, expansion, freezing, and thawing of olfactory mucosa mesenchymal stem/stromal cells was performed, applied to the rat model, as well as a biological characterization of these cells.
To investigate the therapeutic potential of OM-MSCs and their eventual safe application in preclinical trials, the main characteristics of OMSC stemness were addressed.
American Psychological Association (APA)
Alvites, Rui D.& Branquinho, Mariana V.& Caseiro, Ana Rita& Amorim, Irina& Santos Pedrosa, Sílvia& Rêma, A.…[et al.]. 2020. Rat Olfactory Mucosa Mesenchymal StemStromal Cells (OM-MSCs): A Characterization Study. International Journal of Cell Biology،Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1169266
Modern Language Association (MLA)
Alvites, Rui D.…[et al.]. Rat Olfactory Mucosa Mesenchymal StemStromal Cells (OM-MSCs): A Characterization Study. International Journal of Cell Biology No. 2020 (2020), pp.1-21.
https://search.emarefa.net/detail/BIM-1169266
American Medical Association (AMA)
Alvites, Rui D.& Branquinho, Mariana V.& Caseiro, Ana Rita& Amorim, Irina& Santos Pedrosa, Sílvia& Rêma, A.…[et al.]. Rat Olfactory Mucosa Mesenchymal StemStromal Cells (OM-MSCs): A Characterization Study. International Journal of Cell Biology. 2020. Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1169266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1169266