Conceptualization of Heterogeneity of Chronic Diseases and Atherosclerosis as a Pathway to Precision Medicine: Endophenotype, Endotype, and Residual Cardiovascular Risk
Joint Authors
Genkel, Vadim V.
Shaposhnik, Igor I.
Source
International Journal of Chronic Diseases
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The article discusses modern approaches to the conceptualization of pathogenetic heterogeneity in various branches of medical science.
The concepts of endophenotype, endotype, and residual cardiovascular risk and the scope of their application in internal medicine and cardiology are considered.
Based on the latest results of studies of the genetic architecture of atherosclerosis, five endotypes of atherosclerosis have been proposed.
Each of the presented endotypes represents one or another pathophysiological mechanism of atherogenesis, having an established genetic substrate, a characteristic panel of biomarkers, and a number of clinical features.
Clinical implications and perspectives for the study of endotypes of atherosclerosis are briefly reviewed.
American Psychological Association (APA)
Genkel, Vadim V.& Shaposhnik, Igor I.. 2020. Conceptualization of Heterogeneity of Chronic Diseases and Atherosclerosis as a Pathway to Precision Medicine: Endophenotype, Endotype, and Residual Cardiovascular Risk. International Journal of Chronic Diseases،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1169315
Modern Language Association (MLA)
Genkel, Vadim V.& Shaposhnik, Igor I.. Conceptualization of Heterogeneity of Chronic Diseases and Atherosclerosis as a Pathway to Precision Medicine: Endophenotype, Endotype, and Residual Cardiovascular Risk. International Journal of Chronic Diseases No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1169315
American Medical Association (AMA)
Genkel, Vadim V.& Shaposhnik, Igor I.. Conceptualization of Heterogeneity of Chronic Diseases and Atherosclerosis as a Pathway to Precision Medicine: Endophenotype, Endotype, and Residual Cardiovascular Risk. International Journal of Chronic Diseases. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1169315
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1169315