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Degradation Characteristics of a Novel PAF Receptor Antagonist, SY0916, in Aqueous Solution
Joint Authors
Jin, Bo
Zhang, Tingting
Ma, Chen
Wang, Yanan
Yin, Wanting
Zhang, Dongfeng
Huang, Haihong
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
SY0916 has been proven to be a potent treatment agent against rheumatoid arthritis in preclinical studies and has been shown to be safe in phase I clinical trials.
However, SY0916 is unstable in water, which is frequently used in pharmaceutical development processes.
The degradation behaviour and stability of SY0916 in aqueous solutions were investigated at different pH levels, periods of time, and temperatures.
Two degradation products (DPs) were successfully separated and characterized by liquid chromatography coupled to high-resolution tandem mass spectrometry (LC-HRMS/MS), liquid chromatography coupled to nuclear magnetic resonance with solid phase extraction (LC-SPE-NMR), and nuclear magnetic resonance (NMR).
SY0916 decomposed to its α,β-unsaturated ketone in protonic solvents, and the α,β-unsaturated ketone further transformed into its alcohol form through a conjugate addition reaction in aqueous media.
The results of this study indicate that the pH of the buffer solutions should be maintained between 3.0 and 3.6 for maximum SY0916 stability.
Factors that affect degradation should be carefully controlled to mitigate or avoid drug decay.
American Psychological Association (APA)
Jin, Bo& Wang, Yanan& Zhang, Tingting& Yin, Wanting& Zhang, Dongfeng& Huang, Haihong…[et al.]. 2019. Degradation Characteristics of a Novel PAF Receptor Antagonist, SY0916, in Aqueous Solution. Journal of Analytical Methods in Chemistry،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1169343
Modern Language Association (MLA)
Jin, Bo…[et al.]. Degradation Characteristics of a Novel PAF Receptor Antagonist, SY0916, in Aqueous Solution. Journal of Analytical Methods in Chemistry No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1169343
American Medical Association (AMA)
Jin, Bo& Wang, Yanan& Zhang, Tingting& Yin, Wanting& Zhang, Dongfeng& Huang, Haihong…[et al.]. Degradation Characteristics of a Novel PAF Receptor Antagonist, SY0916, in Aqueous Solution. Journal of Analytical Methods in Chemistry. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1169343
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1169343