Incidence and Risk Factors for Infections Requiring Hospitalization, Including Pneumocystis Pneumonia, in Japanese Patients with Rheumatoid Arthritis
Joint Authors
Nogi, Shinichi
Komiya, Akiko
Hashimoto, Atsushi
Matsui, Toshihiro
Tohma, Shigeto
Suto, Shiori
Horie, Kouichiro
Fukuda, Hidefumi
Iwata, Kanako
Tsuno, Hirotaka
Ogihara, Hideki
Kawakami, Misato
Furukawa, Hiroshi
Source
International Journal of Rheumatology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Rheumatoid arthritis (RA) may be complicated by different infections, but risk factors for these are not fully elucidated.
Here, we assessed the incidence of and risk factors for infections requiring hospitalization (IRH) including pneumocystis pneumonia (PCP) in patients with RA.
Methods.
We retrospectively surveyed all RA patients treated at our hospital from 2009 to 2013, for whom data were available on demographic features, medications, comorbidities, and severity of RA.
Multivariate logistic regression analysis was applied to calculate adjusted odds ratios (ORs) for factors associated with the occurrence of IRH.
Results.
In a total of 9210 patient-years (2688 patients), there were 373 IRH (3.7/100 patient-years).
Respiratory tract infections were most frequent (n=154, and additionally 16 PCP), followed by urinary tract infections (n=50).
Significant factors for PCP included higher age (≥70 years; OR 3.5), male sex (6.6), underlying lung disease (3.0), use of corticosteroids (4.8), and use of biologics (5.4).
Use of methotrexate (5.7) was positively associated with PCP but negatively with total infections (0.7).
Additionally, functional disorders and higher RA disease activity were also related to total infections.
Conclusions.
Risk factors for infection should be taken into account when deciding treatment for the individual RA patient.
American Psychological Association (APA)
Hashimoto, Atsushi& Suto, Shiori& Horie, Kouichiro& Fukuda, Hidefumi& Nogi, Shinichi& Iwata, Kanako…[et al.]. 2017. Incidence and Risk Factors for Infections Requiring Hospitalization, Including Pneumocystis Pneumonia, in Japanese Patients with Rheumatoid Arthritis. International Journal of Rheumatology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1169379
Modern Language Association (MLA)
Hashimoto, Atsushi…[et al.]. Incidence and Risk Factors for Infections Requiring Hospitalization, Including Pneumocystis Pneumonia, in Japanese Patients with Rheumatoid Arthritis. International Journal of Rheumatology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1169379
American Medical Association (AMA)
Hashimoto, Atsushi& Suto, Shiori& Horie, Kouichiro& Fukuda, Hidefumi& Nogi, Shinichi& Iwata, Kanako…[et al.]. Incidence and Risk Factors for Infections Requiring Hospitalization, Including Pneumocystis Pneumonia, in Japanese Patients with Rheumatoid Arthritis. International Journal of Rheumatology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1169379
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1169379