Safety Assessment of Neoadjuvant Pertuzumab Combined with Trastuzumab in Nonmetastatic HER2-Positive Breast Cancer in Postmenopausal Elderly Women of South Asia
Joint Authors
Hussain, Nadia
Said, Amira S. A.
Khan, Zainab
Source
International Journal of Breast Cancer
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aim.
To evaluate the safety issues and adverse effects of using TCHP regimen (docetaxel, carboplatin, trastuzumab, and pertuzumab) versus TCP regimen (docetaxel, carboplatin, and trastuzumab) in older postmenopausal women with nonmetastatic HER2-positive breast cancer.
HER2 overexpressed in 20–25% of breast cancer signals an aggressive form of breast cancer and is treated with trastuzumab and pertuzumab.
Methods.
The patient record database was accessed to identify all postmenopausal women in the Punjab Care hospital who were above 65 years old, with stages 1–3 HER2-positive breast cancer and treated with neoadjuvant TCHP and neoadjuvant TCP from 2013 till 2016.
Results.
In TCH-P group and TCH group, mild fatigue (34% versus 36%) and diarrhea (48% versus 49%) were most common toxicities.
Fever in TCH-P group and TCH group (12% versus 13%) was common.
Anorexia affected 21% and 16% of patients receiving TCH and TCHP regimen, respectively.
Febrile neutropenia was higher in TCH-P group 13% (3/23) versus 4.5% (1/22) in TCH group.
Also 27.2% (6/22) of TCH-P group was hospitalized for treatment related toxicities versus 21.7% (5/23) of TCH group.
Conclusion.
Comparing neoadjuvant TCP and neoadjuvant TCH-P showed TCH-P regimen had an acceptable toxicity profile.
Severe cardiac dysfunction was not observed.
Using TCH-P regimen can be considered as relatively safe therapeutic option for elderly postmenopausal women with nonmetastatic HER2-positive breast cancer.
American Psychological Association (APA)
Hussain, Nadia& Said, Amira S. A.& Khan, Zainab. 2018. Safety Assessment of Neoadjuvant Pertuzumab Combined with Trastuzumab in Nonmetastatic HER2-Positive Breast Cancer in Postmenopausal Elderly Women of South Asia. International Journal of Breast Cancer،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1169456
Modern Language Association (MLA)
Hussain, Nadia…[et al.]. Safety Assessment of Neoadjuvant Pertuzumab Combined with Trastuzumab in Nonmetastatic HER2-Positive Breast Cancer in Postmenopausal Elderly Women of South Asia. International Journal of Breast Cancer No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1169456
American Medical Association (AMA)
Hussain, Nadia& Said, Amira S. A.& Khan, Zainab. Safety Assessment of Neoadjuvant Pertuzumab Combined with Trastuzumab in Nonmetastatic HER2-Positive Breast Cancer in Postmenopausal Elderly Women of South Asia. International Journal of Breast Cancer. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1169456
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1169456