Impact of Saliva and Cariogenic Microbiota on the Chemotherapy-Induced Oral Mucositis in Oncopediatric Patients: A Preliminary Longitudinal Study
Joint Authors
Bonan, Paulo Rogério Ferreti
Valença, Ana Maria Gondim
Costa, Raphael Cavalcante
Bezerra, Paula Maria Maracajá
Damascena, Lecidamia Cristina Leite
Ribeiro, Isabella Lima Arrais
Sousa, Simone Alves de
Almeida, Leopoldina de Fátima Dantas
Source
International Journal of Dentistry
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study aims to evaluate the salivary parameters and cariogenic microbiota of pediatric oncological patients and their correlation with severe oral mucositis (SOM).
A preliminary longitudinal study included patients in the age range from 4 to 18 years (n = 26), with diagnosis of primary cancer, who were followed up before and after time intervals of two, five, and ten weeks of induction chemotherapy.
Oral mucosa examinations were performed by means of the modified Oral Assessment Guide (OAG) by calibrated examiners (κ > 0.70).
Saliva analysis (unstimulated saliva flow (USF), clinical saliva viscosity (CSV), and pH) and microbiological (total Streptococcus (TS) and Streptococcus of the mutans group (SMG)) tests were performed using unstimulated saliva.
The data were analyzed by the Wilcoxon and Spearman Correlation tests (α = 5%).
The patients were predominantly of the female sex (n = 15; 57.7%), adolescents (n = 15; 57.7%), and patients with hematological tumors (n = 21; 80.8%).
SOM was more frequent in the tenth week (n = 7; 28.6%).
The values of USF, CSV, pH, TS, and SMG were not changed by the institution of chemotherapy (p>0.05).
These values were correlated with SOM and the time, TS and SMG, and CSV and SMG.
The salivary and microbiological parameters investigated did not influence the severity of oral mucositis in the pediatric patients oncological..
American Psychological Association (APA)
Costa, Raphael Cavalcante& Bezerra, Paula Maria Maracajá& Damascena, Lecidamia Cristina Leite& Ribeiro, Isabella Lima Arrais& Bonan, Paulo Rogério Ferreti& Sousa, Simone Alves de…[et al.]. 2020. Impact of Saliva and Cariogenic Microbiota on the Chemotherapy-Induced Oral Mucositis in Oncopediatric Patients: A Preliminary Longitudinal Study. International Journal of Dentistry،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1169508
Modern Language Association (MLA)
Costa, Raphael Cavalcante…[et al.]. Impact of Saliva and Cariogenic Microbiota on the Chemotherapy-Induced Oral Mucositis in Oncopediatric Patients: A Preliminary Longitudinal Study. International Journal of Dentistry No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1169508
American Medical Association (AMA)
Costa, Raphael Cavalcante& Bezerra, Paula Maria Maracajá& Damascena, Lecidamia Cristina Leite& Ribeiro, Isabella Lima Arrais& Bonan, Paulo Rogério Ferreti& Sousa, Simone Alves de…[et al.]. Impact of Saliva and Cariogenic Microbiota on the Chemotherapy-Induced Oral Mucositis in Oncopediatric Patients: A Preliminary Longitudinal Study. International Journal of Dentistry. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1169508
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1169508