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The Role of Endoplasmic Reticulum Stress in Cardiovascular Disease and Exercise
Joint Authors
Park, Yoonjung
Hong, Junyoung
Kim, Kwangchan
Kim, Jong-Hee
Source
International Journal of Vascular Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Endoplasmic reticulum (ER) stress, which is highly associated with cardiovascular disease, is triggered by a disturbance in ER function because of protein misfolding or an increase in protein secretion.
Prolonged disruption of ER causes ER stress and activation of the unfolded protein response (UPR) and leads to various diseases.
Eukaryotic cells respond to ER stress via three major sensors that are bound to the ER membrane: activating transcription factor 6 (ATF6), inositol-requiring protein 1α (IRE1α), and protein kinase RNA-like ER kinase (PERK).
Chronic activation of ER stress causes damage in endothelial cells (EC) via apoptosis, inflammation, and oxidative stress signaling pathways.
The alleviation of ER stress has recently been accepted as a potential therapeutic target to treat cardiovascular diseases such as heart failure, hypertension, and atherosclerosis.
Exercise training is an effective nonpharmacological approach for preventing and alleviating cardiovascular disease.
We here review the recent viewing of ER stress-mediated apoptosis and inflammation signaling pathways in cardiovascular disease and the role of exercise in ER stress-associated diseases.
American Psychological Association (APA)
Hong, Junyoung& Kim, Kwangchan& Kim, Jong-Hee& Park, Yoonjung. 2017. The Role of Endoplasmic Reticulum Stress in Cardiovascular Disease and Exercise. International Journal of Vascular Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1169788
Modern Language Association (MLA)
Hong, Junyoung…[et al.]. The Role of Endoplasmic Reticulum Stress in Cardiovascular Disease and Exercise. International Journal of Vascular Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1169788
American Medical Association (AMA)
Hong, Junyoung& Kim, Kwangchan& Kim, Jong-Hee& Park, Yoonjung. The Role of Endoplasmic Reticulum Stress in Cardiovascular Disease and Exercise. International Journal of Vascular Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1169788
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1169788