ABO Gene Polymorphism and Thrombomodulin −33G>A Polymorphism Were Not Risk Factors for Myocardial Infarction in Javanese Men
Joint Authors
Rohman, Mohammad Saifur
Lukitasari, Mifetika
Sadewa, Ahmad Hamim
Source
International Journal of Vascular Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Genetic factors contribute to about a half of coronary artery diseases.
During the last several decades, some studies suggested that non-O blood group and thrombomodulin polymorphism −33G>A are the risk factors of coronary artery disease especially in Asia.
There was no prior study in Indonesia regarding this issue.
Hence, this study was designed to investigate the correlation of ABO polymorphism and thrombomodulin polymorphism −33G>A with the incidence of acute myocardial infarction (AMI).
A total of 192 subjects were enrolled in this case control study.
AMI patients were diagnosed based on World Health Organization criteria.
Healthy patients were subjects with AMI risk factor without any sign and symptoms of AMI.
Patients with diabetes mellitus, cancer, and arrhythmia were excluded from this study.
Genotyping for both polymorphisms was performed by PCR RFLP methods.
The result of this study suggested that ABO polymorphism and thrombomodulin polymorphism −33G>A were not risk factors of AMI, p=0.727 and p=0.699, respectively.
Furthermore, the analysis to identify the synergy of these polymorphisms failed to prove their correlation with AMI (p=0.118).
Conclusively, this study showed that ABO polymorphism and thrombomodulin polymorphism −33G>A were not risk factors of AMI.
American Psychological Association (APA)
Lukitasari, Mifetika& Sadewa, Ahmad Hamim& Rohman, Mohammad Saifur. 2017. ABO Gene Polymorphism and Thrombomodulin −33G>A Polymorphism Were Not Risk Factors for Myocardial Infarction in Javanese Men. International Journal of Vascular Medicine،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1169794
Modern Language Association (MLA)
Lukitasari, Mifetika…[et al.]. ABO Gene Polymorphism and Thrombomodulin −33G>A Polymorphism Were Not Risk Factors for Myocardial Infarction in Javanese Men. International Journal of Vascular Medicine No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1169794
American Medical Association (AMA)
Lukitasari, Mifetika& Sadewa, Ahmad Hamim& Rohman, Mohammad Saifur. ABO Gene Polymorphism and Thrombomodulin −33G>A Polymorphism Were Not Risk Factors for Myocardial Infarction in Javanese Men. International Journal of Vascular Medicine. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1169794
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1169794