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Pentraxin 3 Levels in Young Women with and without Polycystic Ovary Syndrome (PCOS) in relation to the Nutritional Status and Systemic Inflammation
Joint Authors
Madej, Paweł
Owczarek, Aleksander
Franik, Grzegorz
Choręza, Piotr
Wyskida, Katarzyna
Olszanecka-Glinianowicz, Magdalena
Pohl, Natalia
Markuszewski, Leszek
Chudek, Jerzy
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
The aim of the study was to assess PTX3 levels in PCOS and non-PCOS women in relation to nutritional status and circulating markers of inflammation.
Methods.
The study enrolled 99 stable body mass PCOS women (17 normal weight, 21 overweight, and 61 obese) and 61 non-PCOS women (24 normal weight, 19 overweight, and 18 obese).
Body composition was assessed by bioimpedance, and plasma levels of pentraxin 3 (PTX3), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and monocyte chemoattractant protein 1 (MCP-1) were measured.
Homeostatic model assessment of insulin resistance (HOMA-IR) was made.
Results.
Plasma PTX3, TNF-α, and IL-6 levels and HOMA-IR were higher in PCOS than in non-PCOS group p<0.001.
There were positive correlations between log10 (PTX3) and log10 (BMI), waist circumference and fat percentage, as well as log10 (HOMA-IR) and free androgen index but negative between log10 (estradiol) levels in PCOS.
While in the non-PCOS group, the correlations between log10 (PTX3) and log10 (BMI), waist circumference and fat percentage, as well as log10 (HOMA-IR) were negative.
The positive correlations between PTX3 and MPC-1 and log10 (IL-6) were shown in the PCOS group only.
In multivariate regression analyses, variability in PTX3 levels in the PCOS group was proportional to log10 (BMI), waist circumference, and fat percentage, but inversely proportional to log10 (estradiol) levels.
While in the non-PCOS group, PTX3 levels were inversely proportional to all anthropometric parameters.
Conclusions.
Our results show that the decrease in PTX3 levels observed in obese is distorted in PCOS by microinflammation, and possibly, dysfunction of stroma adipose tissue and liver steatosis is reflected by enhanced insulin resistance.
American Psychological Association (APA)
Wyskida, Katarzyna& Franik, Grzegorz& Choręza, Piotr& Pohl, Natalia& Markuszewski, Leszek& Owczarek, Aleksander…[et al.]. 2020. Pentraxin 3 Levels in Young Women with and without Polycystic Ovary Syndrome (PCOS) in relation to the Nutritional Status and Systemic Inflammation. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1170071
Modern Language Association (MLA)
Wyskida, Katarzyna…[et al.]. Pentraxin 3 Levels in Young Women with and without Polycystic Ovary Syndrome (PCOS) in relation to the Nutritional Status and Systemic Inflammation. International Journal of Endocrinology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1170071
American Medical Association (AMA)
Wyskida, Katarzyna& Franik, Grzegorz& Choręza, Piotr& Pohl, Natalia& Markuszewski, Leszek& Owczarek, Aleksander…[et al.]. Pentraxin 3 Levels in Young Women with and without Polycystic Ovary Syndrome (PCOS) in relation to the Nutritional Status and Systemic Inflammation. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1170071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170071