Physiological Effect of Ghrelin on Body Systems
Joint Authors
Akalu, Yonas
Molla, Meseret Derbew
Dessie, Gashaw
Ayelign, Birhanu
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-26, 26 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-25
Country of Publication
Egypt
No. of Pages
26
Main Subjects
Abstract EN
Ghrelin is a relatively novel multifaceted hormone that has been found to exert a plethora of physiological effects.
In this review, we found/confirmed that ghrelin has effect on all body systems.
It induces appetite; promotes the use of carbohydrates as a source of fuel while sparing fat; inhibits lipid oxidation and promotes lipogenesis; stimulates the gastric acid secretion and motility; improves cardiac performance; decreases blood pressure; and protects the kidneys, heart, and brain.
Ghrelin is important for learning, memory, cognition, reward, sleep, taste sensation, olfaction, and sniffing.
It has sympatholytic, analgesic, antimicrobial, antifibrotic, and osteogenic effects.
Moreover, ghrelin makes the skeletal muscle more excitable and stimulates its regeneration following injury; delays puberty; promotes fetal lung development; decreases thyroid hormone and testosterone; stimulates release of growth hormone, prolactin, glucagon, adrenocorticotropic hormone, cortisol, vasopressin, and oxytocin; inhibits insulin release; and promotes wound healing.
Ghrelin protects the body by different mechanisms including inhibition of unwanted inflammation and induction of autophagy.
Having a clear understanding of the ghrelin effect in each system has therapeutic implications.
Future studies are necessary to elucidate the molecular mechanisms of ghrelin actions as well as its application as a GHSR agonist to treat most common diseases in each system without any paradoxical outcomes on the other systems.
American Psychological Association (APA)
Akalu, Yonas& Molla, Meseret Derbew& Dessie, Gashaw& Ayelign, Birhanu. 2020. Physiological Effect of Ghrelin on Body Systems. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-26.
https://search.emarefa.net/detail/BIM-1170075
Modern Language Association (MLA)
Akalu, Yonas…[et al.]. Physiological Effect of Ghrelin on Body Systems. International Journal of Endocrinology No. 2020 (2020), pp.1-26.
https://search.emarefa.net/detail/BIM-1170075
American Medical Association (AMA)
Akalu, Yonas& Molla, Meseret Derbew& Dessie, Gashaw& Ayelign, Birhanu. Physiological Effect of Ghrelin on Body Systems. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-26.
https://search.emarefa.net/detail/BIM-1170075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170075