Inexpensive Apparatus for Fabricating Microspheres for 5-Fluorouracil Controlled Release Systems
Joint Authors
Barbosa, Hanniman Denizard Cosme
Santos, Bárbara Fernanda Figueiredo dos
Tavares, Albaniza Alves
Barbosa, Rossemberg Cardoso
Fook, Marcus Vinícius Lia
Canedo, Eduardo Luis
Silva, Suédina Maria de Lima
Source
International Journal of Chemical Engineering
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-22
Country of Publication
Egypt
No. of Pages
8
Abstract EN
The aim of this study was to develop an inexpensive apparatus for fabricating microspheres, based on chitosan, for 5-fluorouracil (5-FU) controlled release.
Chitosan microspheres were prepared by precipitation method and the effects of manufacturing parameters (injection and airflow rates) on size distribution microspheres were analyzed by optical and scanning electron microscopy.
The results show that the manufacturing parameters, injection and airflow rates, determine the microsphere size distribution.
By modulating these parameters, it was possible to produce chitosan microspheres as small as 437 ± 44 μm and as large as 993 ± 18 μm.
Chitosan microspheres loaded with 5-FU were also produced using the experimental equipment.
The obtained microspheres presented 5-FU controlled release, indicating that the microspheres can be used orally, since they are capable of crossing the stomach barrier and of continuing with the process of 5-FU release.
American Psychological Association (APA)
Barbosa, Hanniman Denizard Cosme& Santos, Bárbara Fernanda Figueiredo dos& Tavares, Albaniza Alves& Barbosa, Rossemberg Cardoso& Fook, Marcus Vinícius Lia& Canedo, Eduardo Luis…[et al.]. 2018. Inexpensive Apparatus for Fabricating Microspheres for 5-Fluorouracil Controlled Release Systems. International Journal of Chemical Engineering،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1170091
Modern Language Association (MLA)
Barbosa, Hanniman Denizard Cosme…[et al.]. Inexpensive Apparatus for Fabricating Microspheres for 5-Fluorouracil Controlled Release Systems. International Journal of Chemical Engineering No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1170091
American Medical Association (AMA)
Barbosa, Hanniman Denizard Cosme& Santos, Bárbara Fernanda Figueiredo dos& Tavares, Albaniza Alves& Barbosa, Rossemberg Cardoso& Fook, Marcus Vinícius Lia& Canedo, Eduardo Luis…[et al.]. Inexpensive Apparatus for Fabricating Microspheres for 5-Fluorouracil Controlled Release Systems. International Journal of Chemical Engineering. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1170091
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170091