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GLP-1GLP-1R Signaling Regulates Ovarian PCOS-Associated Granulosa Cells Proliferation and Antiapoptosis by Modification of Forkhead Box Protein O1 Phosphorylation Sites
Joint Authors
Sun, Zhi-Hua
Chen, Zhi
Shen, Jie
Li, Peiyi
Wang, Xiao
Lai, Shuchang
Qiu, Hong
Hu, Shidi
Yao, Jie
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
As the major cause of female anovulatory infertility, polycystic ovary syndrome (PCOS) affects a great proportion of women at childbearing age.
Although glucagon-like peptide 1 receptor agonists (GLP-IRAs) show therapeutic effects for PCOS, its target and underlying mechanism remains elusive.
In the present study, we identified that, both in vivo and in vitro, GLP-1 functioned as the regulator of proliferation and antiapoptosis of MGCs of follicle in PCOS mouse ovary.
Furthermore, forkhead box protein O1 (FoxO1) plays an important role in the courses.
Regarding the importance of granulosa cells (GCs) in oocyte development and function, the results from the current study could provide a more detailed illustration on the already known beneficial effects of GLP-1RAs on PCOS and support the future efforts to develop more efficient GLP-1RAs for PCOS treatment.
American Psychological Association (APA)
Sun, Zhi-Hua& Li, Peiyi& Wang, Xiao& Lai, Shuchang& Qiu, Hong& Chen, Zhi…[et al.]. 2020. GLP-1GLP-1R Signaling Regulates Ovarian PCOS-Associated Granulosa Cells Proliferation and Antiapoptosis by Modification of Forkhead Box Protein O1 Phosphorylation Sites. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1170093
Modern Language Association (MLA)
Sun, Zhi-Hua…[et al.]. GLP-1GLP-1R Signaling Regulates Ovarian PCOS-Associated Granulosa Cells Proliferation and Antiapoptosis by Modification of Forkhead Box Protein O1 Phosphorylation Sites. International Journal of Endocrinology No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1170093
American Medical Association (AMA)
Sun, Zhi-Hua& Li, Peiyi& Wang, Xiao& Lai, Shuchang& Qiu, Hong& Chen, Zhi…[et al.]. GLP-1GLP-1R Signaling Regulates Ovarian PCOS-Associated Granulosa Cells Proliferation and Antiapoptosis by Modification of Forkhead Box Protein O1 Phosphorylation Sites. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1170093
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170093