Effect of Denosumab on Glucose Homeostasis in Postmenopausal Women with Breast Cancer Treated with Aromatase Inhibitors: A Pilot Study
Joint Authors
Rossini, Alessandro
Frigerio, Sofia
Perseghin, Gianluca
Corbetta, Sabrina
Trevisan, Roberto
Dozio, Elena
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Aromatase inhibitors in women with breast cancer have been associated with cancer treatment-induced bone loss (CTIBL), increased fracture risk, and impairment of glucose metabolism.
Denosumab (Dmab), a monoclonal antibody against RANKL, which is a key regulator of the osteoclast activity, is effective as an antiresorptive agent in the treatment of CTIBL.
Since RANKL/RANK pathway may contribute to the pathogenesis of glucometabolic disorders, it has been suggested that Dmab may improve glucose homeostasis.
Our pilot study evaluated the effect of a single administration of 60 mg Dmab on glucose metabolism in a cohort of women with breast cancer treated with aromatase inhibitors.
Methods.
Fifteen postmenopausal nondiabetic women were prospectively enrolled.
Oral glucose tolerance test (OGTT) and metabolic parameters, including FGF21, were assessed at baseline and one month after Dmab injection.
Midterm glucose control was evaluated by measuring glycated haemoglobin (HbA1c) levels 5 months after Dmab.
Results.
Parameters of glucose metabolism were not different one month after Dmab but circulating FGF21 levels significantly decreased (128.5 ± 46.8 versus 100.2 ± 48.8 pg/mL; p=0.016).
Considering patients with insulin resistance at baseline (HOMA-IR > 2.5 and Matsuda Index < 2.5; n = 5), reduced mean fasting insulin levels (16.3 ± 4.9 versus 13.5 ± 3.5 mcU/mL; p=0.029) and increased insulin sensitivity index QUICKI (0.317 ± 0.013 versus 0.327 ± 0.009; p=0.025) were found.
Nonetheless, HbA1c increased 5 months after Dmab (36.0 ± 2.3 versus 39.6 ± 3.1 mmol/mol; p=0.01).
Conclusions.
Although RANKL blockade induced a short-term positive effect on insulin sensitivity, particularly in insulin-resistant patients, a benefit on long-term glucose metabolism was not evident.
In conclusion, Dmab is safe for glucose metabolism in aromatase inhibitor-treated women with breast cancer.
American Psychological Association (APA)
Rossini, Alessandro& Frigerio, Sofia& Dozio, Elena& Trevisan, Roberto& Perseghin, Gianluca& Corbetta, Sabrina. 2020. Effect of Denosumab on Glucose Homeostasis in Postmenopausal Women with Breast Cancer Treated with Aromatase Inhibitors: A Pilot Study. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170112
Modern Language Association (MLA)
Rossini, Alessandro…[et al.]. Effect of Denosumab on Glucose Homeostasis in Postmenopausal Women with Breast Cancer Treated with Aromatase Inhibitors: A Pilot Study. International Journal of Endocrinology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1170112
American Medical Association (AMA)
Rossini, Alessandro& Frigerio, Sofia& Dozio, Elena& Trevisan, Roberto& Perseghin, Gianluca& Corbetta, Sabrina. Effect of Denosumab on Glucose Homeostasis in Postmenopausal Women with Breast Cancer Treated with Aromatase Inhibitors: A Pilot Study. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170112