Cardiac Abnormalities in Acromegaly Patients: A Cardiac Magnetic Resonance Study
Joint Authors
Guo, Xiaopeng
Xing, Bing
Wang, Zihao
Cao, Jian
Liu, Peijun
Cao, Yihan
Li, Xiao
Gao, Lu
Fang, Ligang
Jin, Zhengyu
Wang, Yining
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cardiac abnormalities are the most common and deadly comorbidities of acromegaly.
Assessments using cardiac magnetic resonance (CMR) imaging in acromegaly patients are rare.
We aimed to evaluate the frequencies of left ventricular hypertrophy (LVH), interventricular septum hypertrophy (IVSH), LV systolic dysfunction (LVSD), right ventricular systolic dysfunction (RVSD), and myocardial fibrosis (MCF) and detailed quantitative parameters in acromegaly patients using CMR and analyze their correlations with clinical features.
Sixty-one patients were enrolled in this study.
The rates of LVH, IVSH, LVSD, RVSD, and MCF were 26.2%, 27.9%, 8.2%, 9.8%, and 14.8%, respectively.
The average LV mass, LV mass index, IVS thickness, LV and RV free wall thickness, and LV and RV ejection fractions were 114.4 g, 60.0 g/m2, 9.6 mm, 7.2 mm, 2.9 mm, 59.9%, and 56.6%, respectively.
The LV mass index was larger (68.9 ± 26.0 vs.
48.8 ± 10.6 g/m2), the IVS was thicker (10.3 ± 2.8 vs.
8.8 ± 1.8 mm), and the LV (57.6 ± 12.3% vs.
62.8 ± 4.8%) and RV ejection fractions (54.6 ± 8.7% vs.
59.2 ± 5.9%) were lower in male patients than in female patients (all p<0.05).
Age, body mass index (BMI), disease duration, and hypertension were associated with cardiac abnormalities (all p<0.05).
In conclusion, structural and functional cardiac abnormalities can be comprehensively evaluated by CMR in acromegaly patients.
Gender greatly affects the presence of cardiac abnormalities.
Age, BMI, disease duration, and hypertension but not GH or IGF-1 levels are associated clinical factors.
American Psychological Association (APA)
Guo, Xiaopeng& Cao, Jian& Liu, Peijun& Cao, Yihan& Li, Xiao& Gao, Lu…[et al.]. 2020. Cardiac Abnormalities in Acromegaly Patients: A Cardiac Magnetic Resonance Study. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1170135
Modern Language Association (MLA)
Guo, Xiaopeng…[et al.]. Cardiac Abnormalities in Acromegaly Patients: A Cardiac Magnetic Resonance Study. International Journal of Endocrinology No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1170135
American Medical Association (AMA)
Guo, Xiaopeng& Cao, Jian& Liu, Peijun& Cao, Yihan& Li, Xiao& Gao, Lu…[et al.]. Cardiac Abnormalities in Acromegaly Patients: A Cardiac Magnetic Resonance Study. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1170135
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170135