Clinical and Metabolic Effects of Alpha-Lipoic Acid Associated with Two Different Doses of Myo-Inositol in Women with Polycystic Ovary Syndrome
Joint Authors
Benelli, Elena
Fruzzetti, Franca
Fidecicchi, Tiziana
Tonacchera, Massimo
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this retrospective study was to evaluate the effects of a treatment with α-lipoic acid (ALA) associated with two different doses of myo-inositol (MI) on clinical and metabolic features of women with polycystic ovary syndrome (PCOS).
Eighty-eight women received the treatment, and 71 among them had complete clinical charts and were considered eligible for this study.
All women were treated with 800 mg of ALA per day: 43 patients received 2000 mg of MI and 28 received 1000 mg of MI per day.
Menstrual cyclicity, BMI, FSH, LH, estradiol, testosterone, androstenedione, fasting insulin, HOMA-IR, and insulin response to a 2 h OGTT were evaluated before and after 6 months of treatment.
The presence of diabetic relatives (DRs) was investigated.
Cycle regularity was improved in 71.2% of women.
The improvement of menstrual cyclicity occurred regardless of the state of IR and the presence of DRs of the patients.
Women with IR mainly showed a significant improvement of metabolic parameters, while those without IR had significant changes of reproductive hormones.
Patients with DRs did not show significant changes after the treatment.
85.7% of women taking 2000 mg of MI reported a higher improvement of menstrual regularity than those taking 1000 mg of MI (50%; p<0.01).
In conclusion, ALA + MI positively affects the menstrual regularity of women with PCOS, regardless of their metabolic phenotype, with a more evident effect with a higher dose of MI.
This effect seems to be insulin independent.
The presence of IR seems to be a predictor of responsivity to the treatment in terms of an improvement of the metabolic profile.
American Psychological Association (APA)
Fruzzetti, Franca& Benelli, Elena& Fidecicchi, Tiziana& Tonacchera, Massimo. 2020. Clinical and Metabolic Effects of Alpha-Lipoic Acid Associated with Two Different Doses of Myo-Inositol in Women with Polycystic Ovary Syndrome. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170184
Modern Language Association (MLA)
Fruzzetti, Franca…[et al.]. Clinical and Metabolic Effects of Alpha-Lipoic Acid Associated with Two Different Doses of Myo-Inositol in Women with Polycystic Ovary Syndrome. International Journal of Endocrinology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1170184
American Medical Association (AMA)
Fruzzetti, Franca& Benelli, Elena& Fidecicchi, Tiziana& Tonacchera, Massimo. Clinical and Metabolic Effects of Alpha-Lipoic Acid Associated with Two Different Doses of Myo-Inositol in Women with Polycystic Ovary Syndrome. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170184