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Neuromuscular Blockade Correlates with Hormones and Body Composition in Acromegaly
Joint Authors
Huang, Yuguang
Guo, Xiaopeng
Tan, Gang
Zhao, Mengyun
Chen, Wei
Shi, Xiaodong
Pei, Lijian
Xing, Bing
Zhang, Yu
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Tumor resection is the first-line therapy for acromegaly patients.
In some cases, unsatisfactory intraoperative neuromuscular blockades (NMBs) lead to failed operations.
The purpose of this study was to investigate and quantify the NMB status of acromegaly patients and explore the relationship between NMB status and hormone levels and body composition.
Twenty patients with untreated acromegaly and seventeen patients with nonfunctioning pituitary adenomas as controls were enrolled in this study.
NMB was assessed using the train-of-four (TOF) technique with TOF-Watch® SX.
The onset time of NMB, deep neuromuscular blockade duration (DNMBD), and clinical neuromuscular blockade duration (CNMBD) were monitored.
We found a significantly longer onset time (110.25 ± 54.90 vs.
75.00 ± 27.56, s, p=0.017), shorter DNMBD (21.99 ± 5.67 vs.
34.96 ± 11.04, min, p<0.001), and shorter CNMBD (33.26 ± 8.09 vs.
46.21 ± 10.89, min, p<0.001) in acromegaly patients compared with the controls.
DNMBD and CNMBD decreased in patients with decreasing body fat percentage and increasing growth hormone (GH) level, insulin-like growth factor 1 (IGF-1) level, and GH and IGF-1 burden.
The onset time increased with increasing IGF-1 level and GH and IGF-1 burden.
Taken together, a unique NMB status was identified in acromegaly patients with the following characteristics: prolonged onset time and shortened DNMBD and CNMBD.
Changes in the levels and burdens of GH and IGF-1 and body composition were linearly correlated with intraoperative NMB in acromegaly patients.
American Psychological Association (APA)
Zhang, Yu& Guo, Xiaopeng& Tan, Gang& Zhao, Mengyun& Huang, Yuguang& Chen, Wei…[et al.]. 2020. Neuromuscular Blockade Correlates with Hormones and Body Composition in Acromegaly. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170189
Modern Language Association (MLA)
Zhang, Yu…[et al.]. Neuromuscular Blockade Correlates with Hormones and Body Composition in Acromegaly. International Journal of Endocrinology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1170189
American Medical Association (AMA)
Zhang, Yu& Guo, Xiaopeng& Tan, Gang& Zhao, Mengyun& Huang, Yuguang& Chen, Wei…[et al.]. Neuromuscular Blockade Correlates with Hormones and Body Composition in Acromegaly. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170189