BKCa Mediates Dysfunction in High Glucose Induced Mesangial Cell Injury via TGF-β1Smad23 Signaling Pathways
Joint Authors
Wu, Zhigui
Yin, Wenxian
Sun, Mengqi
Si, Yuankai
Wu, Xiaoxiao
Chen, Meijuan
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
To explore the role and mechanism of BKCa in diabetic kidney disease.
Methods.
Rat mesangial cells (MCs) HBZY-1 were cultured with high glucose to simulate the high-glucose environment of diabetic kidney disease in vivo.
The effects of large conductance calcium-activated potassium channel (BKCa) on proliferation, migration, and apoptosis of HBZY-1 cells were observed.
The contents of transforming growth factor beta 1 (TGF-β1), Smad2/3, collagen IV (Col IV), and fibronectin (FN) in the extracellular matrix were also observed.
Results.
High glucose significantly damaged HBZY-1 cells, which enhanced the ability of cell proliferation, migration, and apoptosis, and increased the secretion of Col IV and FN.
Inhibition of BKCa and TGF-β1/Smad2/3 signaling pathways can inhibit the proliferation, migration, and apoptosis of HBZY-1 cells and suppress the secretion of Col IV and FN.
The effect of excitation is the opposite.
Conclusions.
BKCa regulates mesangial cell proliferation, migration, apoptosis, and secretion of Col IV and FN and is associated with TGF-β1/Smad2/3 signaling pathway.
American Psychological Association (APA)
Wu, Zhigui& Yin, Wenxian& Sun, Mengqi& Si, Yuankai& Wu, Xiaoxiao& Chen, Meijuan. 2020. BKCa Mediates Dysfunction in High Glucose Induced Mesangial Cell Injury via TGF-β1Smad23 Signaling Pathways. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1170230
Modern Language Association (MLA)
Wu, Zhigui…[et al.]. BKCa Mediates Dysfunction in High Glucose Induced Mesangial Cell Injury via TGF-β1Smad23 Signaling Pathways. International Journal of Endocrinology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1170230
American Medical Association (AMA)
Wu, Zhigui& Yin, Wenxian& Sun, Mengqi& Si, Yuankai& Wu, Xiaoxiao& Chen, Meijuan. BKCa Mediates Dysfunction in High Glucose Induced Mesangial Cell Injury via TGF-β1Smad23 Signaling Pathways. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1170230
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170230