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Supercritical Fluid Chromatography of Drugs: Parallel Factor Analysis for Column Testing in a Wide Range of Operational Conditions
Joint Authors
Al Bakain, Ramia Z.
Al-Degs, Yahya
Andri, Bertyl
Thiébaut, Didier
Vial, Jérôme
Rivals, Isabelle
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Retention mechanisms involved in supercritical fluid chromatography (SFC) are influenced by interdependent parameters (temperature, pressure, chemistry of the mobile phase, and nature of the stationary phase), a complexity which makes the selection of a proper stationary phase for a given separation a challenging step.
For the first time in SFC studies, Parallel Factor Analysis (PARAFAC) was employed to evaluate the chromatographic behavior of eight different stationary phases in a wide range of chromatographic conditions (temperature, pressure, and gradient elution composition).
Design of Experiment was used to optimize experiments involving 14 pharmaceutical compounds present in biological and/or environmental samples and with dissimilar physicochemical properties.
The results showed the superiority of PARAFAC for the analysis of the three-way (column × drug × condition) data array over unfolding the multiway array to matrices and performing several classical principal component analyses.
Thanks to the PARAFAC components, similarity in columns’ function, chromatographic trend of drugs, and correlation between separation conditions could be simply depicted: columns were grouped according to their H-bonding forces, while gradient composition was dominating for condition classification.
Also, the number of drugs could be efficiently reduced for columns classification as some of them exhibited a similar behavior, as shown by hierarchical clustering based on PARAFAC components.
American Psychological Association (APA)
Al Bakain, Ramia Z.& Al-Degs, Yahya& Andri, Bertyl& Thiébaut, Didier& Vial, Jérôme& Rivals, Isabelle. 2017. Supercritical Fluid Chromatography of Drugs: Parallel Factor Analysis for Column Testing in a Wide Range of Operational Conditions. Journal of Analytical Methods in Chemistry،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1170236
Modern Language Association (MLA)
Al Bakain, Ramia Z.…[et al.]. Supercritical Fluid Chromatography of Drugs: Parallel Factor Analysis for Column Testing in a Wide Range of Operational Conditions. Journal of Analytical Methods in Chemistry No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1170236
American Medical Association (AMA)
Al Bakain, Ramia Z.& Al-Degs, Yahya& Andri, Bertyl& Thiébaut, Didier& Vial, Jérôme& Rivals, Isabelle. Supercritical Fluid Chromatography of Drugs: Parallel Factor Analysis for Column Testing in a Wide Range of Operational Conditions. Journal of Analytical Methods in Chemistry. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1170236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170236