Mitochondrial DNA: A New Predictor of Diabetic Kidney Disease
Joint Authors
Wang, Yangang
Huang, Yajing
Chi, Jingwei
Wei, Fanxiang
Zhou, Yue
Cao, Yihai
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Diabetic kidney disease (DKD) is a common cause of end-stage renal disease, and diagnosis and treatment in time can help delay its progress.
At present, there are more and more studies on the pathogenesis of DKD; mitochondrial dysfunction plays an important role in DKD.
The occurrence and development of DKD is closely related to epigenetic changes and the interaction between mtDNA, ROS, inflammatory factors, and endothelial damage, which continuously aggravates kidney.
The change of mtDNA is both the cause of DKD and the result of DKD.
It is of great significance to incorporate the change of mtDNA into the monitoring of patients with diabetes.
Existing evidence indicates that changes in mtDNA copy number in blood and urine reflect mitochondrial dysfunction and the severity of DKD.
However, large-scale, long-term follow-up clinical trials are still needed to determine the threshold range.
By the time, mitochondrial-targeted antioxidants will become a new method for the treatment of DKD and other diabetic complications; mtDNA also can be a therapeutic target for them.
American Psychological Association (APA)
Huang, Yajing& Chi, Jingwei& Wei, Fanxiang& Zhou, Yue& Cao, Yihai& Wang, Yangang. 2020. Mitochondrial DNA: A New Predictor of Diabetic Kidney Disease. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1170248
Modern Language Association (MLA)
Huang, Yajing…[et al.]. Mitochondrial DNA: A New Predictor of Diabetic Kidney Disease. International Journal of Endocrinology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1170248
American Medical Association (AMA)
Huang, Yajing& Chi, Jingwei& Wei, Fanxiang& Zhou, Yue& Cao, Yihai& Wang, Yangang. Mitochondrial DNA: A New Predictor of Diabetic Kidney Disease. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1170248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170248