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Pre- and Postoperative Health Status of Patients with Nonfunctioning and Secretory Pituitary Adenomas and an Analysis of Related Factors
Joint Authors
Guo, Xiaopeng
Xing, Bing
Wang, Zihao
Gao, Lu
Zhang, Yi
Wang, Lijun
Guo, Jinzhu
Zhao, Haiyan
Sun, Shuang
Sun, Yanxia
Xu, Dongrui
Feng, Ming
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
To identify the characteristics of the physical and mental health status of patients with pituitary adenomas, explore the postoperative reversibility of impaired health status, and assess the impact of clinical characteristics, hormone levels, anxiety, depression, and disease stigma on health status.
Methods.
We prospectively enrolled 147 and 138 patients with nonfunctioning and secretory pituitary adenomas, respectively.
Health status was evaluated in 8 domains using the 36-item Short-Form Health Survey before and 3 months after transsphenoidal surgery.
The Self-Rating Anxiety Scale, the Self-Rating Depression Scale, and the Stigma Scale for Chronic Illness were used to assess the psychological status.
Results.
Compared with the healthy population reference values, general physical and mental health, social functioning, and role limitations due to physical and psychological health problems were all found to be significantly impaired in the adenoma patients.
Health status was worse in patients with adrenocorticotropic hormone- (ACTH-) secreting and growth hormone- (GH-) secreting adenomas than in patients with nonfunctioning adenomas.
Among the patients, 11.6% had anxiety and 30.9% had depression.
Higher scores for anxiety, depression, and disease stigma; older age; higher body mass index; and tumor recurrence were independent risk factors for health status impairment in at least one domain.
Physical function impairment and role limitations caused by physical health problems became worse after surgery, whereas the mental component of health status remained the same.
Conclusion.
Health status was impaired in patients with pituitary adenomas, especially secretory adenomas.
Physical function and role limitations were worse 3 months after surgery than before surgery.
Mental problems, old age, obesity, and tumor recurrence reduced health status.
American Psychological Association (APA)
Zhang, Yi& Guo, Xiaopeng& Wang, Lijun& Guo, Jinzhu& Zhao, Haiyan& Sun, Shuang…[et al.]. 2020. Pre- and Postoperative Health Status of Patients with Nonfunctioning and Secretory Pituitary Adenomas and an Analysis of Related Factors. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170277
Modern Language Association (MLA)
Zhang, Yi…[et al.]. Pre- and Postoperative Health Status of Patients with Nonfunctioning and Secretory Pituitary Adenomas and an Analysis of Related Factors. International Journal of Endocrinology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1170277
American Medical Association (AMA)
Zhang, Yi& Guo, Xiaopeng& Wang, Lijun& Guo, Jinzhu& Zhao, Haiyan& Sun, Shuang…[et al.]. Pre- and Postoperative Health Status of Patients with Nonfunctioning and Secretory Pituitary Adenomas and an Analysis of Related Factors. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170277
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170277