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Peripheral Spexin Inhibited Food Intake in Mice
Joint Authors
Lv, Shuangyu
Zhou, Yuchen
Feng, Yu
Zhang, Xiaomei
Wang, Xinyue
Yang, Yanjie
Wang, Xinchun
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Spexin (SPX, NPQ), a novel endogenous neuropeptide, was firstly identified by bioinformatics.
Spexin gene and protein widely distributed in the central nervous system and peripheral tissues, such as the hypothalamus and digestive tract.
The role of spexin in appetite regulation in mammalian is still unclear.
The present study was designed to investigate the mechanism and effect of peripheral spexin on food intake in mice.
During the light period, an intraperitoneal (i.p.) injection of spexin (10 nmol/mouse) significantly inhibited cumulative food intake at 2, 4, and 6 h after treatment in fasted mice.
During the dark period, spexin (1 and 10 nmol/mouse, i.p.) significantly suppressed cumulative food intake at 4 and 6 h after treatment in freely feeding mice.
The GALR3 antagonist SNAP37889, not GALR2 antagonist, significantly antagonized the inhibitory effect on cumulative food intake (0–6 h) induced by spexin.
Spexin significantly reduced the mRNA level of Npy mRNA, not Agrp, Pomc, Cart, Crh, Orexin, or Mch, in the hypothalamus.
Spexin (10 nmol/mouse, i.p.) increased the number of c-Fos positive neurons in hypothalamic AHA and SCN, but not in ARC, DMN, LHA, PVN, SON, or VMH.
The hypothalamic p-CaMK2 protein expression was upregulated by spexin.
This study indicated that acute peripheral injection of spexin inhibited mouse food intake.
The anorectic effect may be mediated by GALR3, and inhibiting neuropeptide Y (NPY) via p-CaMK2 and c-Fos in the hypothalamus.
American Psychological Association (APA)
Lv, Shuangyu& Zhou, Yuchen& Feng, Yu& Zhang, Xiaomei& Wang, Xinyue& Yang, Yanjie…[et al.]. 2020. Peripheral Spexin Inhibited Food Intake in Mice. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1170325
Modern Language Association (MLA)
Lv, Shuangyu…[et al.]. Peripheral Spexin Inhibited Food Intake in Mice. International Journal of Endocrinology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1170325
American Medical Association (AMA)
Lv, Shuangyu& Zhou, Yuchen& Feng, Yu& Zhang, Xiaomei& Wang, Xinyue& Yang, Yanjie…[et al.]. Peripheral Spexin Inhibited Food Intake in Mice. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1170325
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170325