Recovery of Prenatal Baicalein Exposure Perturbed Reproduction by Postnatal Exposure of Testosterone in Male Mice
Joint Authors
Vaadala, Sridevi
Ponneri, Naveen
Karanam, Venkata Shashank
Sainath, Sri Bhashyam
Reddy, Pamanji Sreenivasuala
Pamuru, Ramachandra Reddy
Mohammed, Arifullah
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Baicalein (BC), a flavonoid, which lacks the qualities of reproductive health and shows adverse effects, is tested in this study.
Inseminated mice were injected with 30, 60, and 90 mg BC/Kg body weight on gestation days 11, 13, 15, and 17.
The F1 BC-exposed males of each dosage were divided into six groups.
First three groups (n = 6 from each BC dosage) were used for assessment of reproductive performance, the others (n = 4 from each BC dosage) were administered with testosterone 4.16 mg/kg body weight on postnatal days 21, 31, and 41.
The reproductive health of adult F1 males at the age of 55 and 60 was tested.
Prenatal BC exposure showed reduced fertility after cohabitation with control females.
The BC exposure significantly reduced the body weight, tissue indices, and sperm parameters (motility, count, viability, and daily sperm count) and altered the sperm membrane in a hypoosmotic swelling test.
A downward trend was observed in testicular steroidogenic marker enzymes (3β- and 17β-steroid dehydrogenases) and serum testosterone, whereas increase in serum titers of FSH and LH along with altered the testicular histology.
Conversely, testosterone (4.16 mg/kg body weight) partially recovered reduced male reproductive health by BC.
BC impaired male reproductive health due to low levels of testosterone is reverted by external testosterone is evidenced in this study.
American Psychological Association (APA)
Vaadala, Sridevi& Ponneri, Naveen& Karanam, Venkata Shashank& Sainath, Sri Bhashyam& Reddy, Pamanji Sreenivasuala& Pamuru, Ramachandra Reddy…[et al.]. 2020. Recovery of Prenatal Baicalein Exposure Perturbed Reproduction by Postnatal Exposure of Testosterone in Male Mice. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1170330
Modern Language Association (MLA)
Vaadala, Sridevi…[et al.]. Recovery of Prenatal Baicalein Exposure Perturbed Reproduction by Postnatal Exposure of Testosterone in Male Mice. International Journal of Endocrinology No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1170330
American Medical Association (AMA)
Vaadala, Sridevi& Ponneri, Naveen& Karanam, Venkata Shashank& Sainath, Sri Bhashyam& Reddy, Pamanji Sreenivasuala& Pamuru, Ramachandra Reddy…[et al.]. Recovery of Prenatal Baicalein Exposure Perturbed Reproduction by Postnatal Exposure of Testosterone in Male Mice. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1170330
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170330