Application of 19F NMR Spectroscopy for Content Determination of Fluorinated Pharmaceuticals
Joint Authors
Lachenmeier, Dirk W.
Kuballa, Thomas
Okaru, Alex O.
Brunner, Tobias S.
Ackermann, Svenja M.
Walch, Stephan G.
Kohl-Himmelseher, Matthias
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A simple, rapid, and selective quantitative nuclear magnetic resonance spectroscopic method was evaluated for the determination of the content of fluorinated pharmaceuticals.
19F NMR spectra were either obtained in dimethylsulfoxide-d6 or aqueous buffer, using trifluoroacetic acid as internal standard.
Quantification of 13 fluorine-containing pharmaceuticals spanning various pharmacological classes was accomplished using the proposed method.
The method was found to be fit for purpose (interday precision 1.2% relative standard deviation) and may thus be applied for routine analysis and quality control of fluorine-containing pharmaceuticals due to its simplicity, nondestructive sample measurement, reliability, and high specificity.
Therefore, 19F NMR may serve as a suitable analytical tool for the identification and selective determination of fluorinated pharmaceuticals used as reference materials and bulk samples.
American Psychological Association (APA)
Okaru, Alex O.& Brunner, Tobias S.& Ackermann, Svenja M.& Kuballa, Thomas& Walch, Stephan G.& Kohl-Himmelseher, Matthias…[et al.]. 2017. Application of 19F NMR Spectroscopy for Content Determination of Fluorinated Pharmaceuticals. Journal of Analytical Methods in Chemistry،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1170350
Modern Language Association (MLA)
Okaru, Alex O.…[et al.]. Application of 19F NMR Spectroscopy for Content Determination of Fluorinated Pharmaceuticals. Journal of Analytical Methods in Chemistry No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1170350
American Medical Association (AMA)
Okaru, Alex O.& Brunner, Tobias S.& Ackermann, Svenja M.& Kuballa, Thomas& Walch, Stephan G.& Kohl-Himmelseher, Matthias…[et al.]. Application of 19F NMR Spectroscopy for Content Determination of Fluorinated Pharmaceuticals. Journal of Analytical Methods in Chemistry. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1170350
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170350