Quality of Life in Patients with Acromegaly before and after Transsphenoidal Surgical Resection
Joint Authors
He, Min
Wang, Meng
Gu, Jing
Xiang, Shiyuan
Gu, Yanfang
Li, Lingjuan
Yin, Zhiwen
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
We aimed to determine the perioperative changes in the quality of life (QoL) in patients with acromegaly and to reveal the relationship between biochemical indicators and quality of life change after tumor resection.
Methods.
Patients with acromegaly were enrolled from a tertiary pituitary center.
SF-36 scale and AcroQoL scale were used to determine the QoL before and after surgery.
We analyzed changes in QoL using a generalized linear model for repeated measurements.
We compared the changes in QoL among three groups (remission, active, and discordant group) based on postoperative growth hormone (GH) and insulin-like growth factor-1.
Results.
151 patients (75 males and 76 females) diagnosed with acromegaly were included.
The average age was 43.9 ± 12.3 years.
The median total SF-36 scale was 65.3% (IQR: 63.2%–69.2%).
Overall AcroQoL score at baseline was 59.1% (IQR: 51.8%–71.8%).
Nadir GH levels (coefficient −0.08, p=0.047), T3 levels (coefficient 2.8, p=0.001), and testosterone levels (coefficient −0.20, p=0.033) in males were independent predictive factors of the total SF-36 score.
During the follow-up, the median overall SF-36 score increased to 66.1% at 3 months and 75.3% at 6 months (p<0.001) after surgery.
The median overall AcroQoL score increased to 74.5% at 3 months and 77.3% at 6 months (p<0.001) after surgery.
At 6-month follow-up, median scores were still less than 70% in appearance, vitality, and mental health dimensions.
The QoL after surgery were similar among the three groups, although higher GH and more preoperative somatostatin analogs usage were observed in the active group.
Conclusion.
In conclusion, acromegalic patients were associated with low QoL, which could be reversed partially by surgery.
The improvement was independent of the endocrine remission.
Appearance, vitality, and mental health were three major aspects that warrant further attention from physicians and caregivers after surgery.
American Psychological Association (APA)
Gu, Jing& Xiang, Shiyuan& He, Min& Wang, Meng& Gu, Yanfang& Li, Lingjuan…[et al.]. 2020. Quality of Life in Patients with Acromegaly before and after Transsphenoidal Surgical Resection. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1170357
Modern Language Association (MLA)
Gu, Jing…[et al.]. Quality of Life in Patients with Acromegaly before and after Transsphenoidal Surgical Resection. International Journal of Endocrinology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1170357
American Medical Association (AMA)
Gu, Jing& Xiang, Shiyuan& He, Min& Wang, Meng& Gu, Yanfang& Li, Lingjuan…[et al.]. Quality of Life in Patients with Acromegaly before and after Transsphenoidal Surgical Resection. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1170357
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170357