Anabolic Hormone Deficiencies in Heart Failure with Reduced or Preserved Ejection Fraction and Correlation with Plasma Total Antioxidant Capacity
Joint Authors
Meucci, Elisabetta
Favuzzi, Angela Maria Rita
Bruno, Carmine
Nicolazzi, Maria Anna
Vergani, Edoardo
Ciferri, Nunzia
Nicolotti, Nicola
D’Assante, Roberta
Cittadini, Antonio
Silvestrini, Andrea
Mancini, Antonio
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
While anabolic hormone deficit is a common finding in heart failure with reduced ejection fraction (HFrEF), few data are available in heart failure with preserved ejection fraction (HFpEF).
Methods.
Blood samples were collected for metabolic (total cholesterol, HDL cholesterol, LDL cholesterol, creatinine, and glucose) and hormonal (IGF-1, DHEA-S, TSH, fT3, fT4, and T) determination, comparing 30 patients with HFpEF and 20 patients with HFrEF.
Total antioxidant capacity was evaluated by using the spectrophotometric method using the latency time in the appearance of the radical species of a chromogen (LAG, sec) as a parameter proportional to antioxidant content of the sample.
Echocardiographic parameters were also assessed in the two groups.
Results.
A high prevalence of testosterone (32% in HFrEF and 72% in HFpEF, p<0.05) and DHEA-S deficiencies was observed in HFpEF patients.
Echocardiographic parameters did not correlate with hormone values.
A significant direct correlation between T (r2 = 0.25, p<0.05) and DHEA-S (r2 = 0.19, p<0.05) with LAG was observed only in HFpEF.
Conclusion.
Anabolic hormone deficiency is clearly shown in HFpEF, as already known in HFrEF.
Although longitudinal studies are required to confirm the prognostic value of this observation, our data suggest different mechanisms in modulating antioxidants in the two conditions, with possible therapeutic implications.
American Psychological Association (APA)
Mancini, Antonio& Favuzzi, Angela Maria Rita& Bruno, Carmine& Nicolazzi, Maria Anna& Vergani, Edoardo& Ciferri, Nunzia…[et al.]. 2020. Anabolic Hormone Deficiencies in Heart Failure with Reduced or Preserved Ejection Fraction and Correlation with Plasma Total Antioxidant Capacity. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1170384
Modern Language Association (MLA)
Mancini, Antonio…[et al.]. Anabolic Hormone Deficiencies in Heart Failure with Reduced or Preserved Ejection Fraction and Correlation with Plasma Total Antioxidant Capacity. International Journal of Endocrinology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1170384
American Medical Association (AMA)
Mancini, Antonio& Favuzzi, Angela Maria Rita& Bruno, Carmine& Nicolazzi, Maria Anna& Vergani, Edoardo& Ciferri, Nunzia…[et al.]. Anabolic Hormone Deficiencies in Heart Failure with Reduced or Preserved Ejection Fraction and Correlation with Plasma Total Antioxidant Capacity. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1170384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170384